血清球蛋白/胆碱酯酶与乙肝后肝硬化门脉高压的关系  

Study on the relationship between serum globulin/cholinesterase and portal hypertension with liver cirrhosis after hepatitis B

作　　者：周红宇[1] 周昌文 廖娜娜[1] 陈叶青[1] 周国华[1] ZHOU Hong-yu;ZHOU Chang-wen;LIAO Na-na;CHEN Ye-qing;ZHOU Guo-hua(Department of Gastroenterology,the 922 Hospital of PLA,the Xiangnan Affiliated Hospital of Hunan Normal University,Hengyang,421002 Hunan,China)

机构地区：[1]中国人民解放军第922医院暨湖南师范大学附属湘南医院消化内科,湖南衡阳421002

出　　处：《临床消化病杂志》2022年第2期111-114,共4页Chinese Journal of Clinical Gastroenterology

基　　金：湖南省课题血清球蛋白/胆碱酯酶比值对肝硬化肝功能储备及预后评估的价值(No:C20170214)。

摘　　要：[目的]探讨乙肝后肝硬化患者血清球蛋白/胆碱酯酶(G/C)与门脉高压的关系。[方法]选取符合条件的142例乙肝后失代偿期肝硬化患者进行回顾性分析。根据入院时G/C将所选患者分为3组:G/C≥0.5~≤1.0组、G/C>1.0~≤2.0组、G/C>2.0组。对比分析3组的脾脏厚度、门静脉及脾静脉内径、血小板数量、食管静脉曲张情况。[结果](1)脾脏厚度:随G/C增加,逐渐增厚,G/C>1.0~≤2.0组与G/C>2.0组比较差异无统计学意义(P>0.05),但与G/C≥0.5~≤1.0组相比差异有统计学意义(P<0.05);(2)门静脉及脾静脉内径:随G/C增加而增加,G/C>1.0~≤2.0组与G/C>2.0组比较差异无统计学意义(P>0.05),但与G/C≥0.5~≤1.0组相比差异有统计学意义(P<0.05);(3)血小板数量:随G/C增加增加,血小板数量明显下降,3组两两相比差异有统计学意义(P<0.05);(4)食管静脉曲张程度:随G/C增加,静脉曲张程度渐加重,3组在不同程度食管静脉曲张中所占比例差异有统计学意义(P<0.001)。[结论]G/C与乙肝后肝硬化患者门脉高压相关间接指标门静脉及脾静脉内径、血小板数量、食管静脉曲张程度有良好的相关性,对评估门脉高压有一定价值。[Objective]To investigate the relationship between serum globulin/cholinesterase(G/C)and portal hypertension in patients with hepatitis B cirrhosis.[Methods]A retrospective analysis of 142 patients with post-hepatic decompensated cirrhosis treated in the Department of Digestive Medicine from July 2014 to July 2019.The selected patients were divided into three groups according to the G/C at admission: G/C≥0.5-≤1.0 group, G/C>1.0-≤2.0 group, G/C>2.0 group.The spleen thickness, portal vein and splenic vein width, platelet count and esophageal varices of the three groups were compared and analyzed.[Results](1)Spleen thickness gradually increased with the increase of G/C.There was no significant difference between G/C≤2.0 group and G/C>1.0-≤2.0 group.But compared with the G/C≥0.5-≤1.0 group, the difference were statistically significant(P<0.05).(2)Portal and splenic vein width increased with G/C.There was no significant difference between G/C>2.0 group and G/C>1.0-≤2.0 group, G/C≥0.5-≤1.0 group had statistical difference compared with the other two groups(P<0.05).(3)With the increase of G/C,the PLT decreased obviously, and there was a significant difference between the three groups.(4)Esophageal varices degree: with the increase of G/C,the degree of varices gradually increased, the proportion of esophageal varices in the three groups was statistically different in different degrees(P>0.001).[Conclusion]There is a good correlation between G/C and the indirect index of portal hypertension in patients with hepatitis B cirrhosis, which is valuable for evaluating portal hypertension.

关 键 词：肝硬化 血清球蛋白/胆碱酯酶 门脉高压 食管静脉曲张 

分 类 号：R575.2[医药卫生—消化系统]