血管内皮生长因子、糖类抗原125、糖类抗原19-9在宫颈癌中的表达及临床价值  

Expression of vascular endothelial growth factor,carbohydrate antigen 125,and carbohydrate antigen 19-9 in cervical cancer and their clinical value

作　　者：刘亚红[1] 刘艳庆 邱育红[1] LIU Yahong;LIU Yanqing;QIU Yuhong(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学第二附属医院妇产科,陕西咸阳7120000

出　　处：《癌症进展》2022年第7期712-715,共4页Oncology Progress

摘　　要：目的探究血管内皮生长因子(VEGF)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)在宫颈癌中的表达及临床价值。方法收集宫颈病变患者200例,经组织病理学检查确诊宫颈癌82例,良性病变118例。分析不同疾病患者的VEGF、CA125、CA19-9表达水平;比较不同肿瘤直径、分化程度宫颈癌患者VEGF、CA125、CA19-9阳性表达率;分析宫颈癌患者VEGF、CA125、CA19-9水平与临床分期的相关性;分析VEGF、CA125、CA19-9单独及联合检测对宫颈癌的诊断价值。结果宫颈癌患者VEGF、CA125、CA19-9表达水平均明显高于良性病变患者,差异均有统计学意义(P﹤0.01)。肿瘤直径﹥4 cm宫颈癌患者VEGF、CA125、CA19-9阳性表达率均明显高于肿瘤直径≤4 cm患者,差异均有统计学意义(P﹤0.01)。低分化宫颈癌患者VEGF、CA125、CA19-9阳性表达率均高于中高分化患者,差异均有统计学意义(P﹤0.05)。Spearman相关性分析结果显示,宫颈癌患者的VEGF、CA125、CA19-9水平与临床分期均呈正相关(P﹤0.01)。VEGF、CA125、CA19-9联合检测诊断宫颈癌的曲线下面积(AUC)和截断值均高于VEGF、CA125、CA19-9单独检测。结论VEGF、CA125、CA19-9在宫颈癌中的表达水平显著高于良性病变患者,三者表达情况与肿瘤直径、分化程度、临床分期密切相关,对疾病进展有重要提示作用,且可用于宫颈癌诊断,综合临床价值很高。Objective To investigate the expression of vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125),and carbohydrate antigen 19-9(CA19-9)in cervical cancer and their clinical value.Method A total of200 patients with cervical lesions were collected,82 were diagnosed with cervical cancer,and 118 were benign lesions by the histopathological examination.The expression levels of VEGF,CA125,and CA19-9 in patients with different diseases were analyzed.The positive rates of VEGF,CA125,and CA19-9 in cervical cancer patients with different tumor diameters and differentiation grades were compared.The correlation between VEGF,CA125,CA19-9 levels and clinical stage in patients with cervical cancer was analyzed.The diagnostic value of VEGF,CA125,CA19-9 alone and combined detection in cervical cancer was analyzed.Result The expression levels of VEGF,CA125,and CA19-9 in patients with cervical cancer were significantly higher than those in patients with benign lesions,and the differences were statistically significant(P<0.01).The positive rates of VEGF,CA125,and CA19-9 in cervical cancer patients with tumor diameter>4 cm were significantly higher than those in patients with tumor diameter≤4 cm(P<0.01).The positive rates of VEGF,CA125,and CA19-9 in patients with poorly differentiated cervical cancer were higher than those in patients with moderate-to-high differentiation,and the differences were statistically significant(P<0.05).The results of Spearman correlation analysis showed that the levels of VEGF,CA125,and CA19-9 in cervical cancer patients were positively correlated with the clinical stage(P<0.01).The combined detection of VEGF,CA125,and CA19-9 had more area under the curve(AUC)and higher cut-off value in the diagnosis of cervical cancer than the indicators alone.Conclusion The levels of VEGF,CA125,and CA19-9 in cervical cancer are significantly higher than those in benign lesions.The expression of these indicators is closely related to the tumor diameter,differentiation grade,and clinical stage,which hav

关 键 词：宫颈癌 血管内皮生长因子 糖类抗原 

分 类 号：R737.33[医药卫生—肿瘤]