合成源1,4-萘醌类化合物抑菌活性研究进展  

Research Progress in Antibacterial Activities of Synthetic 1,4-Naphthoquinone Compounds

作　　者：梁俸铭 邵利辉 付毅红 王贞超[1,2,3] 欧阳贵平 Liang Fengming;Shao Lihui;Fu Yihong;Wang Zhenchao;Ouyang Guiping(College of Pharmacy,Guizhou University,Guiyang,550025;Center for Fine Chemical Research and Development,Guizhou University,Guiyang,550025;Guizhou Engineering Laboratory for Synthetic Drugs,Guizhou University,Guiyang,550025)

机构地区：[1]贵州大学药学院,贵阳550025 [2]贵州大学精细化工研究开发中心,贵阳550025 [3]贵州大学贵州省合成药物工程实验室,贵阳550025

出　　处：《化学通报》2022年第5期575-582,共8页Chemistry

基　　金：国家自然科学基金项目(21867004,22007022)资助。

摘　　要：1,4-萘醌作为广泛存在的一种物质,其生物活性尤其是抗菌作用受到越来越多的关注。本文对不同取代类型的合成源1,4-萘醌衍生物进行总结,并探讨其抑菌活性及构效关系,发现在1,4-萘醌的2位引入含氨基取代、含硫取代的基团能够提高抗菌活性,且通常含硫取代比氨基取代基团的抗菌活性高。期望本文能为1,4-萘醌类抗菌药物的研发提供参考。1,4-Naphthoquinone is a widely existing substance,and its biological activity has attracted more and more attention,especially in antibacterial aspects.This article summarizes the synthetic 1,4-naphthoquinone derivatives of different substitution types,and discusses their antibacterial activities and structure-activity relationship.It is found that the introduction of amino-substituted and sulfur-containing substitutions at 2-position of 1,4-naphthoquinone can improve the antibacterial activity,and the antibacterial activity of the sulfur-containing substitution is generally higher than that of the amino substitution group.It is hoped that this article can provide a reference for the future research and development of 1,4-naphthoquinone antibacterial drugs.

关 键 词：1 4-萘醌衍生物 抑菌活性 构效关系 

分 类 号：TQ460.1[化学工程—制药化工]