血清CYFRA21⁃1、TSGF及miR⁃93检测在鼻咽癌早期诊断中的应用  

Application of serum CYFRA21⁃1,TSGF and miR⁃93 in the diagnosis of early nasopharyngeal carcinoma

作　　者：柳帅[1] 王振鹏[1] 张治文[2] 宋照营 LIU Shuai;WANG Zhenpeng;ZHANG Zhiwen;SONG Zhaoying(Department of Otolaryngology,Anyang Hospital of Traditional Chinese Medicine,Anyang,Henan,China,455000;Department of Laboratory Medicine,Anyang Hospital of Traditional Chinese Medicine,Anyang,Henan,China,455000)

机构地区：[1]安阳市中医院耳鼻喉科,河南安阳455000 [2]安阳市中医院检验科,河南安阳455000

出　　处：《分子诊断与治疗杂志》2022年第4期623-626,共4页Journal of Molecular Diagnostics and Therapy

摘　　要：目的分析血清细胞角蛋白19片段(CYFRA21⁃1)、恶性肿瘤特异性生长因子(TSGF)、微小RNA⁃93(miR⁃93)检测在鼻咽癌早期诊断中的应用价值。方法选取2018年6月至2020年6月于安阳市中医院接受诊疗的78例早期鼻咽癌患者为鼻咽癌组,根据鼻咽癌临床分期标准分为Ⅰ期48例、Ⅱ期30例。另选取同期的78例鼻咽炎患者为鼻咽炎组,选取同期体检的78例健康成人为对照组。比较各组血清CYFRA21⁃1、TSGF、miR⁃93水平,并绘制受试者工作特征(ROC)曲线分析其诊断价值。结果CYFRA21⁃1、TSGF、miR⁃93水平:鼻咽癌组>鼻咽炎组>对照组,差异均有统计学意义(P<0.05)。Ⅱ期血清CYFRA21⁃1、TSGF、miR⁃93水平高于Ⅰ期,差异均有统计学意义(P<0.05)。ROC曲线分析显示CYFRA21⁃1、TSGF、miR⁃93联合诊断鼻咽癌AUC为0.938,敏感度、特异度分别为91.03%、85.90%,高于单一指标诊断(P<0.05)。结论血清CYFRA21⁃1、TSGF、miR⁃9均可作为早期鼻咽癌的血清标志物,联合三者检测可进一步提升早期鼻咽癌的诊断效能,为鼻咽癌的早期诊断提供可靠的诊断依据。Objective To analyze the application value of serum cytokeratin 19 fragment(CYFRA21⁃1),tumor specific growth factor(TSGF)and microRNA⁃93(miR⁃93)in the diagnosis of early nasopharyngeal carcinoma.Methods 78 patients with early nasopharyngeal carcinoma who were diagnosed and treated in Anyang Hospital of Traditional Chinese Medicine between June 2018 and June 2020 were selected as nasopharyngeal carcinoma group,78 patients with nasopharyngitis were selected as nasopharyngitis group,and 78 healthy adults were selected as the control group.Serum levels of CYFRA21⁃1,TSGF and miR⁃93 were compared among the groups,and the receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of the three indicators.Results The levels of CYFRA21⁃1,TSGF and miR⁃93 decreased in order from the nasopharyngeal carcinoma group,the nasopharyngitis group,to the control group,with statistically significant differences among the groups(P<0.05).The levels of CYFRA21⁃1,TSGF and miR⁃93 were higher in stageⅡthan in stageⅠ,with statistically significant differences(P<0.05).ROC curve analysis found that the AUC of combined diagnosis with the three indicators was 0.938,and the sensitivity and specificity were 91.03%and 85.09%,which were higher than those of single diagnosis.Conclusion Serum CYFRA21⁃1,TSGF and miR⁃9 can be used as serum markers of early nasopharyngeal carcinoma,especially TSGF.Combined use of the three indicators can further improve the diagnostic efficiency for nasopharyngeal carcinoma.

关 键 词：鼻咽癌 细胞角蛋白19片段 恶性肿瘤特异性生长因子 微小RNA⁃93 

分 类 号：R739.63[医药卫生—肿瘤]