急性期视神经脊髓炎谱系病外周血IL-10水平与肢体伤残的相关性分析  

Correlation analysis of interleukin-10 level in peripheral blood and limb disability in patients with acute neuromyelitis optica spectrum disorder

作　　者：李玉玉[1] 马博[1] 孙辉[1] 许娟娟[1] 许力[1] 钱伟东[1] LI Yuyu;MA Bo;SUN Hui;XU Juanjuan;XU Li;QIAN Weidong(Department of Neurology,the First Affiliated Hospital of Bengbu Medical College,Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院神经内科,安徽蚌埠233004

出　　处：《淮海医药》2022年第2期120-123,共4页Journal of Huaihai Medicine

基　　金：蚌埠医学院自然科学重点项目(BYKY2019051ZD)。

摘　　要：目的:探讨视神经脊髓炎谱系疾病(NMOSD)患者肢体伤残与外周血白介素-10(IL-10)表达水平的相关性。方法:收集某院神经内科住院治疗的急性期NMOSD患者40例,根据水通道蛋白4(AQP4-IgG)的检测结果,将患者分为AQP4(+)组(18例)和AQP4(-)组(22例)2个亚组,同时收集同期体检中心体检的年龄、性别与试验组匹配的健康志愿者30例作为健康对照组(HCs)。比较急性期NMOSD患者与健康对照组之间、AQP4(+)组与AQP4(-)组2个亚组之间血清IL-10水平表达的差异,并比较急性期NMOSD患者2个亚组之间诱发因素、临床症状、脊髓受累节段、视觉诱发电位(VEP)异常方面有无差异,针对IL-10表达水平与扩展残疾状况量表(EDSS)评分进行相关性分析。结果:急性期NMOSD患者外周血IL-10水平为(8.60±2.33)pg/mL,明显高于健康对照组的(3.90±2.09)pg/mL,差异有统计学意义(P<0.05);AQP4(+)组和AQP4(-)组2个亚组IL-10表达水平分别为(7.89±2.40)pg/mL、(9.18±2.15)pg/mL,组间比较差异无统计学意义(P>0.05);2个亚组患者在脊髓受累节段方面比较差异有统计学意义(P<0.05),在性别、年龄、诱发因素、临床症状、VEP异常方面比较差异均无统计学意义(P>0.05);NMOSD急性期患者EDSS评分为(4.03±1.76)分,与外周血IL-10表达水平存在负相关性(r=-0.360,P=0.023)。结论:急性期NMOSD患者外周血IL-10表达水平升高,与EDSS评分之间存在负相关性,可作为NMOSD患者发生肢体瘫痪和致残的预测因素。Objective:To investigate the correlation between peripheral blood interleukin-10(IL-10)and the severity of physical disability in neuromyelitis optica spectrum disorder(NMOSD).Methods:A total of 40 patients with acute NMOSD hospitalized in the department of neurology of a hospital were collected.According to the detection results of aquaporin-4(AQP4-IgG),the patients were divided into two subgroups:AQP4(+)group(18 cases)and AQP4(-)group(22 cases).At the same time,30 healthy volunteers matched with the observation groups in age and gender from physical examination center were enrolled as healthy control group(HCs).Comparison was conducted in terms of the differences in serum IL-10 levels between acute NMOSD patients and healthy control group and between AQP4(+)group and AQP4(-)group,and the differences in terms of inducing factors,clinical symptoms,spinal cord involved segments and visual evoked potential(VEP)abnormalities between the two subgroups of acute NMOSD patients.The correlation between IL-10 expression level and Extended Disability Status Scale(EDSS)score was analyzed.Results:The level of IL-10 in peripheral blood of NMOSD patients in acute stage was(8.60±2.33)pg/mL,which was significantly higher than that in the healthy control group(3.90±2.09)pg/mL,the difference being statistically significant(P<0.05).The expression levels of IL-10 in AQP4(+)group and AQP4(-)group were(7.89±2.40)pg/mL and(9.18±2.15)pg/mL respectively,and there was no significant difference between the two subgroups(P>0.05).There were statistically significant differences in spinal cord involvement between the two subgroups(P<0.05),but there were no statistically significant differences in gender,age,inducing factors,clinical symptoms and VEP abnormalities(P>0.05).EDSS score of NMOSD patients in acute stage was(4.03±1.76),which was negatively correlated with IL-10 expression level in peripheral blood(r=-0.360,P=0.023).Conclusion:The expression level of IL-10 in peripheral blood of NMOSD patients in acute stage is increased,and the

关 键 词：视神经脊髓炎谱系病 水通道蛋白4抗体 白介素-10 肢体伤残 相关性分析 

分 类 号：R744.6[医药卫生—神经病学与精神病学]