Hemostatic mechanism of the effect of Jianpi Yiqi Shexue decoction on vascular factors in immune thrombocytopenia model mice  

作　　者：Ruibai Li Wei Ma Haiyan Lang Hao He Liyuan Lv Yayue Zhang Xinyi Chen Li Hou 

机构地区：[1]Department of Oncology and Hematology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing,100700,China [2]School of Pharmacy,Xi'an Medical University,Shaanxi Province,Xi'an,710021,China

出　　处：《Journal of Traditional Chinese Medical Sciences》2022年第2期160-165,共6页中医科学杂志（英文）

基　　金：supported by the National Basic Research Program of China (973 Program, 2013CB531705);the National Natural Science Foundation Youth Project of China(81703903 and 81803904)

摘　　要：Objective: To explore the hemostatic mechanism of Jianpi Yiqi Shexue decoction(JYSD) by regulating vascular factors in an immune thrombocytopenia(ITP) mouse model.Methods: An ITP mouse model was established by the passive-immune modeling method, and interventional drugs used were prednisone tablets and JYSD. The platelet count;vascular activity-related factors v WF, VCAM-1, and TM;and VEGF and b FGF were used as observational indicators.Results: On the 8th day of administration, compared with the model group, platelet counts in the prednisone and JYSD groups increased(both P <.001). Compared with the control group, the levels of v WF, VCAM-1, and TM in the other groups were lower(all P <.05). The VCAM-1 level in the JYSD group was higher than that in the prednisone group(P =.012), but without significant difference compared with the model group(P =.051). The TM level in the JYSD group was the lowest(vs. the model group,P =.047;vs. the prednisone group, P =.006). Compared with the control group, the IOD values of VEGF and b FGF in the other three groups were lower(all P <.01). The IOD values of VEGF in the prednisone and JYSD groups were both higher than those in the model group(P =.002 and P <.001, respectively). The IOD values of b FGF among the model, prednisone, and JYSD groups were not statistically significant(P >.05).Conclusion: A vascular factor disorder is involved in the pathogenesis of ITP. JYSD can increase the platelet count, upregulate VEGF expression, and reduce the TM level. JYSD has the same effect as prednisone tablets in regulating platelet, v WF, VEGF, and b FGF, with a stronger effect in normalizing VCAM-1 and TM levels. The hemostatic mechanism of JYSD is closely related to the effective balance of vascular factors.

关 键 词：Jianpi Yiqi Shexue decoction von Willebrand factor Vascular cell adhesion molecule-1 THROMBOMODULIN Vascular endothelial growth factor Basic fibroblast growth factor 

分 类 号：R285.5[医药卫生—中药学]