宫颈癌术后复发影响因素及HE4、Fib、P16蛋白预测复发价值  

Influencing factors of postoperative cervical cancer recurrence and the levels of human epididymis protein 4,fibrinogen,and P16 gene protein for predicting the recurrence of cervical cancer

作　　者：张丹 张伟 张玉扬 刘诗宇 ZHANG Dan;ZHANG Wei;ZHANG Yuyang;LIU Shiyu(Fukuang General Hospital of Liaoning Health Industry Group,Fushun,Liaoning province,113008)

机构地区：[1]辽宁省健康产业集团抚矿总医院,抚顺113008

出　　处：《中国计划生育学杂志》2022年第2期466-469,共4页Chinese Journal of Family Planning

基　　金：2021年吴阶平基金项目(320.6750.2021-12-1)。

摘　　要：目的:探究宫颈癌术后复发的影响因素及血浆人附睾蛋白4(HE4)、纤维蛋白原(FIB)、P16基因蛋白对复发的预测价值。方法:选取2019年3月-2020年3月本院治疗的宫颈癌患者90例临床资料,根据患者复发情况分为复发组16例与未复发组74例。比较两组资料及术后血HE4、FIB、P16表达水平。经病理学检查诊断确诊,比较HE4、FIB、P16预测宫颈癌术后复发效能。结果:两组年龄、体质指数、吸烟史、宫颈癌家族史未见差异(P>0.05),而肿瘤直径≥4cm、淋巴结转移、临床分期、HE4、FIB、P16阳性表达占比有差异(P<0.05)。相较于未复发组,复发组HE4、FIB水平增加,P16阳性表达率降低(P<0.05)。肿瘤直径≥4cm、有淋巴结转移、临床分期II期、HE4升高、FIB升高、P16阳性表达增加均为术后复发的独立危险因素(P<0.05)。诊断宫颈癌复发,HE4的准确度76.7%、敏感度82.6%、特异度76.8%,FIB的准确度73.8%、敏感度79.4%、特异度73.7%,P16的准确度81.6%、敏感度85.1%、特异度79.7%。结论:HE4、FIB、P16等表达异常为影响宫颈癌术后复发的独立危险因素,对预测宫颈癌术后复发有一定临床意义,且P16相对价值更佳。Objective: To study the influencing factors of postoperative cervical cancer recurrence, and to analyze the levels of human epididymis protein 4(HE4), fibrinogen(FIB), and P16 gene protein(P16) for predicting the recurrence of cervical cancer. Methods: The clinical data of 90 patients with cervical cancer from Mar. 2019 to Mar. 2020 were selected and these patients were divided into group A(16 patients with recurrence of cervical cancer) and group B(74 patients without recurrence of cervical cancer). The general information and the levels of HE4, Fib and P16 of the patients were compared between the two groups. Based on the results of pathological examination, the predictive efficiency for the postoperative recurrence of cervical cancer was compared among the HE4 level, the FIB level, and the P16 level. Results: There were no significant differences in age, the value of body mass index, the smoking history, and the family history of cervical cancer of the patients between the two groups(P>0.05), but there were significant differences in tumor diameter ≥4 cm, the lymph node metastasis rate, the clinical stage, the positive rates of HE4, FIB, and P16 expressions of the patients between the two groups(P<0.05). The levels of HE4 and FIB of the patients in group A were significantly higher than those of the patients in group B, but the positive expression rate of P16 of the patients in group A was significantly lower(P<0.05). The tumor diameter ≥4 cm, the lymph node metastasis, the clinical stage II, the increased levels of HE4 and FIB, and the positive P16 expression of the patients were the independent risk factors of their postoperative recurrence of cervical cancer(P<0.05). The accuracy, the sensitivity, and the specificity of the HE4 level for diagnosing the recurrence of cervical cancer were 76.7%, 82.6%, and 76.8%,respectively.The accuracy,the sensitivity,and the specificity of the FIB level for diagnosing the recurrence of cervical cancer were 73.8%,79.4%,and 73.7%,respectively.The accuracy,the sensitivity

关 键 词：宫颈癌 术后复发 人附睾蛋白4 纤维蛋白原 P16基因 预测价值 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]