LEEP联合干扰素和抗HPV生物蛋白敷料治疗HSIL伴高危型人乳头瘤病毒感染效果  

Clinical efficacy of cervix loop electrosurgical excision procedure combined with interferon and anti-HPV biological protein dressing for treating women with cervical high-grade squamous intraepithelial lesions and high-risk human papilloma virus infection

作　　者：张媛 糜媛媛 谢绮 陈燕 ZHANG Yuan;MI Yuanyuan;XIE Qi;CHEN Yan(Affiliated Hospitial of Jiangnan University,Wuxi,214000;Nancheng Hospital of Dongguan City,Guangdong Province)

机构地区：[1]江南大学附属医院,无锡214000 [2]广东省东莞市南城医院

出　　处：《中国计划生育学杂志》2022年第4期761-764,共4页Chinese Journal of Family Planning

摘　　要：目的:探究宫颈环形电切术(LEEP)联合重组人干扰素α-2b泡腾胶囊和抗HPV生物蛋白敷料治疗宫颈高级别鳞状上皮内病变(HSIL)伴高危型HPV感染的临床疗效。方法:选取2019年1月-2020年12月在本院行LEEP治疗的HSIL伴高危型HPV感染患者分为两组各46例,均行LEEP锥切术,联合组联合重组人干扰素α-2b和抗HPV生物蛋白敷料治疗。比较两组临床疗效,治疗前后HPV病毒载量,Survivin、Ki-67阳性表达率,术后并发症,随访6、12个月高危型HPV转阴情况。结果:联合组宫颈病变治疗总有效率(95.7%)高于对照组(82.6%),各时点效应、组间效应、时点和组间的交互效应均可显著影响HPV病毒载量水平和Survivin、Ki-67阳性率变化,且联合组治疗后HPV病毒载量水平(6.6±0.8)和Survivin(24.0±2.9)%、Ki-67阳性率(19.2±2.1)%下降程度均优于对照组(均P<0.05)。两组宫颈粘连等并发症发生率无差异(P>0.05);联合组术后6个月(87.0%)、12个月(93.5%)转阴率均高于对照组(65.2%、78.3%)(均P<0.05)。结论:LEEP锥切术联合重组人干扰素α?2b和抗HPV生物蛋白敷料对HSIL伴高危型HPV感染患者临床疗效更高,可有效抑制病毒增殖,促进高危型HPV转阴,降低术后复发率。Objective:To explore the clinical efficacy of cervix loop electrosurgical excision procedure(LEEP)combined with recombinant human interferon α-2 beffervescent capsules and anti-HPV bioprotein dressings for treating women with cervical high-grade squamous intraepithelial lesions(HSIL)and high-risk human papilloma virus(HPV)infection.Methods:The women with HSIL and high-risk HPV infection who underwent LEEP treatment were selected and were divided in two groups(46cases in each group)from January 2019to December 2020.The women in the study group were given treatment of LEEP combined with recombinant human interferon α-2 beffervescent capsules and anti-HPV bioprotein dressings additionally.The clinical efficacy,the HPV viral load before and after treatment,the positive expression rates of Survivin and Ki-67,the postoperative complications rate,and the situation of high-risk HPV negative conversion during 6and 12months of followed up of the women were compared between the two groups.Results:The total effective rate of the treatment of cervical lesion(95.7%)of the women in the study group was significantly higher than that(82.6%)of the women in the control group.HPV viral load and positive rates of Survivin and Ki-67were affected significantly by different time point effect,intergroup effect,time point,and intergroup interaction effect.The level of HPV viral load(6.6±0.8),and the degree decreased of the positive rates Survivin(24.0±2.9%)and Ki-67(19.2±2.1%)of the women in the study group after treatment were significantly better than those of the women in the control group(all P<0.05).There were no significant differences in the incidences of complications,such as cervical adhesion and other,of the women between the two groups(P>0.05).The negative rate of the women in the study group in postoperative 6months(87.0%)or in postoperative 12months(93.5%)was significantly higher than that(65.2%or 78.3%)of the women in the control group(all P<0.05).Conclusion:The clinical efficacy of LEEP combined with recombinant human

关 键 词：高级别鳞状上皮内病变 高危型HPV 宫颈环形电切术 重组人干扰素Α-2B 抗HPV生物蛋白敷料 疗效 

分 类 号：R737.33[医药卫生—肿瘤]