X染色体连锁锌指蛋白轴蛋白在胃癌组织中的表达水平及与临床病理因素的相关性分析  

Expression Levels of X-Chromosome-Linked Zinc Finger Protein and Axin in Gastric Cancer Tissues and Correlation with Clinicopathological Factors

作　　者：郑炜[1] 蔡文宝 叶贤刚 ZHENG Wei(The First Affiliated Hospital of Fujian Medical University,Fujian Fuzhou 350005, China)

机构地区：[1]福建医科大学附属第一医院胃肠外科,福建福州350005 [2]福建省泉州市泉港区总医院普外科,福建泉州362800 [3]福建医科大学附属第一医院闽南分院普外科,福建泉州362800

出　　处：《河北医学》2022年第5期745-750,共6页Hebei Medicine

基　　金：福建省自然科学计划项目,(编号:2020N089s)。

摘　　要：目的:分析胃癌组织中X染色体连锁锌指蛋白、轴蛋白表达水平及与临床病理因素的相关性。方法:回顾性选取2018年2月至2021年2月本院胃癌患者300例,将其胃癌组织300例及癌旁组织(与胃癌组织相距5.0cm以上)140例手术切取下来,统计分析胃癌组织和癌旁组织中ZFX、Axin表达情况,并分析胃癌组织中ZFX、Axin表达与临床病理因素的相关性。结果:胃癌组织中ZFX表达阳性率84.33%(253/300)高于癌旁组织17.14%(24/140),阴性率15.67%(47/300)低于癌旁组织82.86%(116/140)(P<0.05);Axin表达阳性率34.00%(102/300)低于癌旁组织84.29%(118/140),阴性率66.00%(198/300)高于癌旁组织15.71%(22/140)(P<0.05)。Duke分期Ⅰ~Ⅱ期患者胃癌组织中ZFX表达阳性率低于Ⅲ~Ⅳ期患者(P<0.05),分化程度低分化、中分化、高分化患者胃癌组织中ZFX表达阳性率逐渐降低(P<0.05),浸润深度黏膜外层、黏膜层、黏膜及其下层患者胃癌组织中ZFX表达阳性率逐渐降低(P<0.05),淋巴结转移患者胃癌组织中ZFX表达阳性率高于淋巴结未转移患者(P<0.05)。Duke分期Ⅰ~Ⅱ期患者胃癌组织中Axin表达阳性率高于Ⅲ~Ⅳ期患者(P<0.05),分化程度低分化、中分化、高分化患者胃癌组织中Axin表达阳性率逐渐升高(P<0.05),浸润深度黏膜外层、黏膜层、黏膜及其下层患者胃癌组织中Axin表达阳性率逐渐升高(P<0.05),淋巴结转移患者胃癌组织中Axin表达阳性率低于淋巴结未转移患者(P<0.05)。结论:胃癌组织中X染色体连锁锌指蛋白表达阳性率提升,轴蛋白表达阳性率降低,均与临床病理因素中Duke分期、分化程度、浸润深度、淋巴结转移相关。Objective:To analyze the expression levels of X-chromosome-linked zinc finger protein and axin expression levels in gastric cancer tissues and their correlation with clinicopathological factors.Methods:From Feb.2018 to Feb.2021,300 patients with gastric cancer in our hospital were retrospectively selected,and 300 cases of their gastric cancer tissues and 140 cases of their paracancerous tissues(more than 5.0 cm away from the gastric cancer tissues)were surgically excised down,and the expression of ZFX and Axin in gastric cancer tissues and paracancerous tissues were statistically analyzed,and the correlation between the expression of ZFX and Axin in gastric cancer tissues and clinicopathological factors was analyzed.Results:The positive rate of ZFX expression in gastric cancer tissues was 84.33%(253/300)higher than that in paraneoplastic tissues 17.14%(24/140),and the negative rate was 15.67%(47/300)lower than that in paraneoplastic tissues 82.86%(116/140)(P<0.05);the positive rate of Axin expression was 34.00%(102/300)lower than that in paraneoplastic tissues 84.29%(118/140)and the negative rate was 66.00%(198/300)higher than that of 15.71%(22/140)in paraneoplastic tissues(P<0.05).The positive rate of ZFX expression in gastric cancer tissues of patients with Duke stage I-II was lower than that of patients with stage III-IV(P<0.05),the positive rate of ZFX expression in gastric cancer tissues of patients with low,medium and high differentiation gradually decreased(P<0.05),the positive rate of ZFX expression in gastric cancer tissues of patients with infiltration depth of outer mucosal layer,mucosal layer,mucosa and submucosa gradually decreased(P<0.05).The positive rate of ZFX expression in gastric cancer tissues of patients with lymph node metastasis was higher than that of patients without lymph node metastasis(P<0.05).The positive rate of Axin expression in gastric cancer tissues of patients with Duke stage I-II was higher than that of patients with stage III-IV(P<0.05).The positive rate of Axin expression in

关 键 词：胃癌组织 X染色体连锁锌指蛋白 轴蛋白 

分 类 号：R73[医药卫生—肿瘤]