成人口腔多灶性朗格汉斯细胞组织细胞增生症1例  

Multifocal oral Langerhans cell histiocytosis in adult:A case report

作　　者：邓小婷 魏子豪 江潞[1] DENG Xiaoting;WEI Zihao;JIANG Lu(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Oral Medicine,West China Hospital of Stomatology,Sichuan Universily,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔黏膜病科,四川成都610041

出　　处：《口腔医学》2022年第4期349-353,共5页Stomatology

基　　金：国家自然科学基金(81872208,82171809)。

摘　　要：朗格汉斯细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)是一种朗格汉斯细胞异常增殖和浸润性疾病,通常累及全身骨骼、皮肤、垂体,亦可累及肝脏、脾、血液系统、肺、淋巴结及中枢神经系统。成年人罕见。LCH缺乏公认的治疗方案,最常见的治疗方法包括手术、局部注射类固醇药物、化疗、放疗或联合治疗。本病案报道1例采用局部小剂量放射治疗的成年男性上下颌骨多灶性LCH,结合该病例的诊治经验及既往文献报道,讨论了口腔单系统LCH合并多灶性骨病变的治疗方案选择。Langerhans cell histiocytosis(LCH),an abnormal proliferative and infiltrative disorder of Langerhans cells,usually involves skeleton,skin,pituitary and can also affect liver,spleen,blood system,lungs,lymph nodes,and central nervous system.LCH is rare in adults.It lacks a recognized therapeutic regimen,and therapies of LCH mainly include surgery,topical injections of steroids,chemotherapy,radiotherapy,and combined therapy.Herein,we report an adult patient with oral single system(SS)-LCH with multifocal bone lesions involving the maxilla and mandible treated with local small-dose radiotherapy.We discuss the therapeutic regimen selection of oral single system LCH combined with multifocal bone lesions,with the help of its diagnosis,treatment experience and previous literature reports.

关 键 词：朗格汉斯细胞组织细胞增生症 成人 口腔 治疗 放射治疗 多灶性 

分 类 号：R781.59[医药卫生—口腔医学]