微创低温等离子甲状软骨板下切除术治疗对声门型喉癌患者临床疗效、发音功能及生活质量的影响  

Effects of Minimally Invasive Hypothermic Plasma Subthyrochondral Resection on Clinical Efficacy,Vocal Function and Quality of Life in Patients with Glottic Laryngeal Carcinoma

作　　者：李韬 李玉杰 LI Tao;LI Yujie(Department of Otolaryngology Head and Neck Surgery,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450000,China)

机构地区：[1]郑州大学附属郑州中心医院耳鼻咽喉头颈外科,河南郑州450000

出　　处：《临床研究》2022年第5期9-12,共4页Clinical Research

基　　金：ERAS理念在成人OSAHS患者围术期的应用探讨(LHGJ2019050)。

摘　　要：目的探讨声门型喉癌患者给予微创低温等离子甲状软骨板下切除术治疗对临床疗效、发音功能及生活质量的影响。方法选取2020年1月至2022年1月郑州大学附属郑州中心医院治疗的声门型喉癌患者88例作为研究对象,按照随机数字表法分成观察组(44例)和对照组(44例),对照组给予垂直半喉切除术治疗,观察组给予微创低温等离子甲状软骨板下切除术治疗,比较两组患者临床疗效、发音功能及生活质量。结果观察组疾病控制率(DCR)(88.64%)较对照组(68.18%)高,差异有统计学意义(P<0.05);两组术后振幅微扰(Shimmer)、基频微扰(Jitter)降低,谐噪比(HNR)提高,差异有统计学意义(P<0.05),观察组Shimmer、Jitter较对照组更低,HNR更高,差异有统计学意义(P<0.05);两组术后总体生命质量、功能评分提高,症状评分降低,差异有统计学意义(P<0.05),观察组总体生命质量、功能评分较对照组更高,症状评分更低,差异有统计学意义(P<0.05)。结论声门型喉癌患者给予微创低温等离子甲状软骨板下切除术治疗,能够提高临床疗效及生活质量,改善发音功能。Objective To investigate the effect of minimally invasive low-temperature plasma subthyroplateectomy on clinical efficacy,vocal function and quality of life in patients with glottic laryngeal carcinoma.Methods A total of 88 patients with glottic laryngeal carcinoma who were treated in Zhengzhou Central Hospital Affiliated to Zhengzhou University from January 2020 to January 2022 were selected as the research subjects,and they were divided into the observation group(44 cases)and the control group(44 cases)according to the random number table method.The control group was treated with vertical hemilaryngotomy,and the observation group was treated with minimally invasive low-temperature plasma subthyroidectomy.The clinical efficacy,pronunciation function and quality of life of the two groups were compared.Results The disease control rate(DCR)of the observation group(88.64%)was significantly higher than that of the control group(68.18%)(P<0.05).The amplitude perturbation(Shimmer)and fundamental frequency perturbation(Jitter)of the two groups after operation were significantly decreased(P<0.05),and the harmonic-to-noise ratio(HNR)was significantly increased(P<0.05),the Shimmer and Jitter in the observation group were significantly lower than those in the control group(P<0.05),and the HNR was significantly higher(P<0.05).The overall quality of life and function scores were significantly improved and the symptom scores were significantly reduced after intervention in two groups(P<0.05),the overall quality of life and function scores of the observation group were significantly higher than those of the control group(P<0.05),and the symptom scores were significantly lower(P<0.05).Conclusion Minimally invasive low-temperature plasma subthyroidectomy for patients with glottic laryngeal carcinoma can improve the clinical efficacy,quality of life,and pronunciation function.

关 键 词：微创低温等离子甲状软骨板下切除术 声门型喉癌 临床疗效 发音功能 生活质量 

分 类 号：R739.65[医药卫生—肿瘤]