还原性谷胱甘肽联合复方甘草酸苷对酒精性肝硬化患者临床疗效探析  

Clinical Effect of Reducing Glutathione Combined with Compound Glycyrrhizin on Patients with Alcoholic Cirrhosis

作　　者：范玉梅 FAN Yumei(Department of Gastroenterology,Zhoukou Central Hospital,Zhoukou Henan 466000,China)

机构地区：[1]周口市中心医院消化科,河南周口466000

出　　处：《临床研究》2022年第5期108-111,共4页Clinical Research

摘　　要：目的探析还原型谷胱甘肽联合复方甘草酸苷治疗酒精性肝硬化的临床价值。方法选取周口市中心医院2019年1月至2020年1月收治的95例酒精性肝硬化患者为研究对象,按照抛硬币法将其分为对照组(47例)和观察组(48例)。两组患者均采取常规治疗措施,与此同时,对照组患者单独应用还原型谷胱甘肽治疗(药物静脉滴注),观察组患者应用复方甘草酸苷联合还原型谷胱甘肽治疗(药物静脉滴注),对比两组治疗效果,治疗前后的肝功能指标[丙氨酸氨基转移酶(ALT)、谷氨酸转肽酶(GGT)及天冬氨酸氨基转移酶(AST)]、肝纤维化指标[肝脏弹性值(FS)]以及炎症因子指标[白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)]变化情况。结果观察组患者临床疗效显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者肝功能指标对比,差异无统计学意义(P>0.05);治疗后,观察组患者ALT、GGT、AST指标低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者FS指标对比,差异无统计学意义(P>0.05);治疗后,观察组患者FS指标高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者血清炎症因子指标对比,差异无统计学意义(P>0.05);治疗后,观察组患者IL-6、TNF-α指标低于对照组,差异有统计学意义(P<0.05)。结论复方甘草酸苷联合还原型谷胱甘肽治疗酒精性肝硬化,疗效显著,能够显著改善各项临床症状和肝脏功能,减缓或控制肝纤维化程度,同时能够加快减轻机体炎症反应,值得临床应用。Objective To study the clinical value of reducing glutathione combined with compound glycyrrhizin in the treatment of alcoholic cirrhosis.A total of 95 patients with alcoholic cirrhosis admitted to Zhoukou Downtown Hospital from January 2019 to January 2020 were selected and divided into two groups according to the coin flipping method.Conventional treatment was taken in both groups.Control group(47 cases)were treated with reduced glutathione alone(drug intravenous drip),Observation group(48 cases)were treated with compound glycyrrhizin combined with reduced glutathione(drug intravenous drip).Compared two groups of treatment effect,and the change of the different period of liver function index[alanine aminotransferase(ALT),glutamate transpeptidase(GGT)and aspartate aminotransferase(AST)],liver fibrosis index[liver elasticity(FS)]and inflammatory factor index[interleukin 6(IL-6),tumor necrosis factor alpha](TNF alpha).Results The clinical efficacy of observation group was significantly higher than control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in liver function indexes between two groups(P>0.05),and ALT,GGT and AST indexes in observation group were lower than those in control group after treatment,the differences were statistically significant(P<0.05).There was no significant difference in FS index between the two groups before treatment(P>0.05),and FS index in the observation group was higher than that in the control group after treatment,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum inflammatory factors between 2 groups(P>0.05),and il-6 and TNF-αin observation group were lower than control group after treatment,the difference was statistically significant(P<0.05).Conclusion Compound glycyrrhizin combined with reduced glutathione in the treatment of alcoholic cirrhosis has an ideal therapeutic effect,which can significantly improve the clinical symptoms and liver function,

关 键 词：酒精性肝硬化 复方甘草酸 还原型谷胱甘肽 肝功能 

分 类 号：R575.2[医药卫生—消化系统]