经支气管镜冷冻肺活检对弥漫性肺疾病与中央型肺癌诊断的有效性及安全性比较  

Comparison of the efficacy and safety of transbronchoscopic frozen lung biopsy in the diagnosis of diffuse lung disease(DLD)and central lung cancer

作　　者：章辉 金伟中 王利民[2] 王娇莉 ZHANG Hui;JIN Weizhong;WANG Limin;WANG Jiaoli(The Fourth Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Respiratory Medicine,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China)

机构地区：[1]浙江中医药大学第四临床医学院,浙江杭州310053 [2]浙江大学医学院附属杭州市第一人民医院呼吸内科,浙江杭州310006

出　　处：《中国现代医生》2022年第11期56-59,共4页China Modern Doctor

基　　金：浙江省自然科学基金(LGF20H010005)。

摘　　要：目的评价经支气管镜冷冻肺活检(TBCB)对弥漫性肺疾病(DLD)与中央型肺癌诊断的有效性及安全性。方法纳入2018年11月至2020年8月分别因胸部CT提示为弥漫性间质性改变及肺门占位并在浙江大学医学院附属杭州市第一人民医院进行TBCB的患者共33例,其中弥漫性间质性改变归为DLD组18例,肺门占位归为中央型肺癌组15例;回顾性对比并分析两组患者的肺功能、TBCB等临床数据。结果DLD组共获得TBCB组织标本63个,平均直径(3.9±0.5)mm;中央型肺癌组共获得TBCB组织标本49个,平均直径(5.1±1.2)mm;两组患者标本的平均直径比较,差异有统计学意义(P<0.05)。DLD组有11例(61.1%)获得明确病理形态学诊断,中央型肺癌组有14例(93.3%)获得明确病理形态学诊断;两组患者的诊断率比较,差异有统计学意义(P<0.05)。根据并发症的分级,将两组患者并发症进行比较,差异有统计学意义(P<0.05)。结论TBCB对于中央型肺癌患者的检出率明显高于DLD患者,前者并发症的严重程度同样高于后者。Objective To evaluate the efficacy and safety of transbronchoscopic frozen lung biopsy(TBCB)in the diagnosis of diffuse lung disease(DLD)and central lung cancer.Methods A total of 33 patients with diffuse lung disease(was classified as DLD group,n=18)and hilar mass suggested Affiliated Hangzhou First People's Hospital,by chest CT as central lung cancer group,(n=15)by chest CT who underwent TBCB in Hangzhou First People′s Hospital from November 2018 to August 2020 and had complete clinical data were selected as the study subjects.The medical history,pulmonary function,chest high-resolution CT,and TBCB findings were retrospectively analyzed and compared between the two groups.Results A total of 63 TBCB tissue samples were obtained from patients in the DLD group,with an average diameter of(3.9±0.5)mm.49 TBCB tissue samples were obtained from patients in the central lung cancer group,with an average diameter of(5.1±1.2)mm.There was a significant difference in the average diameter of the samples between the two groups(P<0.05).Eleven patients(61.1%)with DLD and 14 patients(93.3%)with central lung cancer were diagnosed pathomorphologically.There was significant difference in the diagnostic rate between the two groups(P<0.05).In addition,according to the grade of complications,the differences in the complications between the two groups had statistical significance(P<0.05).Conclusion The detection rate of TBCB in patients with central lung cancer is significantly higher than that in patients with DLD,but the severity of complications in the former is also higher than that in the latter.

关 键 词：支气管镜冷冻肺活检 弥漫性肺疾病 中央型肺癌 诊断 并发症 

分 类 号：R734.2[医药卫生—肿瘤]