吲唑衍生物的合成及抗肿瘤活性研究进展  

Development for synthesis and anti-tumor activity of indazole derivatives

作　　者：陶世林 樊思莉 侯迷 梁俸铭 朱莉 周志旭[1] 王贞超[1,2,3] 欧阳贵平 TAO Shi-lin;FAN Si-li;HOU Mi;LIANG Feng-ming;ZHU Li;ZHOU Zhi-xun;WANG Zhen-chao;OU YANG Gui-ping(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China;Drug Synthetic Engineering Laboratory of Guizhou Province,Guiyang 550025,China;Center for Fine Chemical Research and Development,Guizhou University,Guiyang 550025)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州省合成药物工程实验室,贵州贵阳550025 [3]贵州大学精细化工研究开发中心,贵州贵阳550025

出　　处：《化学研究与应用》2022年第5期937-946,共10页Chemical Research and Application

基　　金：国家自然科学基金项目(21867004,22007022)资助;贵州省科技计划项目(黔科合平台人才[2018]5781号)资助。

摘　　要：吲唑是一类重要的杂环化合物及中间体,是药物中常见的优势骨架。本文概述了2009年到2021年来酰胺类、磺胺类、胺类、杂环类等吲唑衍生物小分子的合成及抗肿瘤活性。Indazoles are important heterocyclic compounds and intermediates,which are common dominant skeletons in drugs.The synthesis and anti-tumor activity development of indazole derivatives with amide,sulfonamide,amine,and other heterocycle moieties from 2009 to 2021 were summarized in this article.

关 键 词：吲唑衍生物 抗肿瘤活性 进展 

分 类 号：O626.13[理学—有机化学]