阿尔茨海默病患者OCTA血流密度改变的Meta分析  

OCTA changes in blood flow density of patients with Alzheimer’s disease:a Meta-analysis

作　　者：邓宇 刘自强 王建伟[1] 李媛媛 接传红[1] Yu Deng;Zi-Qiang Liu;Jian-Wei Wang;Yuan-Yuan Li;Chuan-Hong Jie(Eye Hospital China Academy of Chinese Medical Sciences, Beijing 100029, China)

机构地区：[1]中国中医科学院眼科医院,中国北京市100029

出　　处：《国际眼科杂志》2022年第6期990-996,共7页International Eye Science

基　　金：国家自然科学基金项目面上项目(No.81874494);北京市自然科学基金面上项目(No.7182187);首都卫生发展科研专项(No.2020-2-4182,2020-3-4184);北京市中医药科技发展资金项目(No.JCZX-2020-14);中国中医科学院科技创新工程(No.CI2021A02604)。

摘　　要：目的:使用Meta分析的方法探究阿尔茨海默病(AD)患者视网膜光学相干断层扫描血管成像(OCTA)血流密度的变化情况,并探究OCTA在AD患者早期诊断中的价值。方法:计算机检索2016-01/2021-09 Embase、Pubmed、The Cochrane Library数据库关于AD患者黄斑区血流密度的相关研究,由两位研究员独立筛选文献、提取资料并采用纽卡斯尔-渥太华量表(NOS)评价纳入研究的偏倚风险,使用RevMan 5.3软件进行Meta分析。结果:纳入10篇文献,共计研究对象740例(眼),其中AD组321例,对照组419例(与AD组年龄相匹配且认知能力正常人群)。Meta分析结果显示,AD患者黄斑区浅层血流密度低于对照组(MD=-1.58,95%CI-2.60~-0.55,P=0.003);AD患者黄斑区深层血流密度低于对照组(MD=-2.72,95%CI-4.36~-1.07,P=0.001);AD患者旁中心凹血流密度低于对照组(MD=-1.44,95%CI-1.94~-0.94,P<0.00001);AD患者中心凹无血管区面积略大于对照组(MD=0.05,95%CI-0.01~0.11,P=0.13)。结论:AD患者黄斑区各分层血流密度均降低,OCTA可以辅助早期诊断AD。AIM:To explore the changes of retinal optical coherence tomography angiography(OCTA)vessel density in Patients with Alzheimer’s disease(AD)by Meta-analysis,and to explore the value of OCTA in early diagnosis of AD patients.METHODS:Embase,PubMed and Cochrane Library data were searched from January 2016 to September 2021 for relevant studies on vessel density in macular area of AD patients.Two researchers independently screened the literature,extracted the data,and evaluated the risk of inclusion bias using Newcastle-Ottawa Scale(NOS).Meta-analysis was performed using RevMan 5.3 software.RESULTS:A total of 740 cases(eyes)were included in 10 literatures,including 321 cases from the AD group and 419 cases from the control group(age-matched people with normal cognitive abilities).The results of the Meta-analysis showed that the superficial vessel density in macular area of AD patients was lower than that in control group(MD=-1.58,95%CI-2.60--0.55,P=0.003).The deep vessel density in macular area of AD patients was lower than that in control group(MD=-2.72,95%CI-4.36--1.07,P=0.001).The parafoveal vessel density in AD patients was lower than that in control group(MD=-1.44,95%CI-1.94--0.94,P<0.00001).The avascular area in the fovea of AD patients was slightly larger than that of the control group(MD=0.05,95%CI-0.01-0.11,P=0.13).CONCLUSION:The vessel density of each layer in macular area of AD patients were lower than that of control groups the difference was statistically significant.OCTA can assist in the early diagnosis of AD.

关 键 词：阿尔茨海默病 光相干断层扫描血管成像(OCTA) 微血管损伤 视网膜血流密度 META分析 

分 类 号：R73[医药卫生—肿瘤]