奥沙利铂联合5-氟尿嘧啶在T4期结直肠癌腹腔热灌注治疗中的临床研究  

Oxaliplatin combined with 5-Fluorouracil in treatment of T4 colorectal cancer with hyperthermic intra-peritoneal chemotherapy:a clinical study

作　　者：钟育波[1] 罗兵 邓淑平 胡旭东[3] 余思 邱磊[1] Zhong Yubo;Luo Bing;Deng Shuping;Hu Xudong;Yu Si;Qiu Lei(Department of Gastrointestinal Surgery,Foshan Second Municipal People′s Hospital,Guangdong 528000,China;Huanshi Hospital,Department of Medicine Chancheng Distnct People′s Hospital,Foshan 528000,China;Department of Anesthesiology,Foshan Second Municipal Peolpe′s Hospital,Guangdong 528000,China)

机构地区：[1]广东省佛山市第二人民医院胃肠外科,528000 [2]广东省佛山市禅城区人民医院环市院区,内科528000 [3]广东省佛山市第二人民医院麻醉科,528000

出　　处：《中国药物与临床》2022年第5期407-410,共4页Chinese Remedies & Clinics

基　　金：广东省佛山市医学类科技攻关项目(2018AB002811)。

摘　　要：目的探讨奥沙利铂联合氟尿嘧啶在T4期结直肠癌腹腔热灌注治疗中的安全性和疗效。方法回顾性分析2018年1月至2020年11月佛山市第二人民医院胃肠外科完成的80例经腹腔镜肠癌根治术的结直肠癌患者的临床资料,按是否接受术中或术后早期热灌注治疗(HIPEC)分为治疗组和对照组,治疗组患者在肠癌根治术后早期予以腹腔热灌注化疗,对照组则单纯行腹腔镜结直肠癌根治术,2组术后均给予奥沙利铂+希罗达(XELOX)方案化疗6个月,比较2组患者的的术后并发症、不良反应及预后情况。结果2组患者术中出血量、手术时间、肿瘤细胞减灭满意度(CC)评级和TNM分期差异均无统计学意义(P>0.05);2组吻合口瘘、吻合口出血、腹部感染和肠梗阻的发生率相似(P>0.05);2组胃肠道反应、骨髓抑制及肝功能损害差异无统计学意义(P>0.05);治疗组术后3年的局部复发率明显降低(P<0.05)。结论奥沙利铂联合5-氟尿嘧啶用于HIPEC治疗T4期结直肠癌安全可靠、可行,且对患者预后有益。Objective To determine the safety and efficacy of Oxaliplatin combined with 5-Fluorouracil in the treatment of T4 colorectal cancer(CRC)with hyperthermic intra-peritoneal chemotherapy(HIPEC).Methods The clinical data of 80 patients with CRC,who underwent laparoscopic radical resection of CRC between January 2018 and November 2020 in the Department of Gastrointestinal Surgery,Foshan Second Municipal People′s Hospital,were retrospectively analyzed.All patients were divided into the treatment group(HIPEC)and control group according to whether they received intraoperative or early postoperative HIPEC.The treatment group was given HIPEC at the early stage after radical resection of CRC.The control group underwent simple laparoscopic radical resection of CRC.Both groups were given XELOX chemotherapy for 6 months after operation.The postoperative complications,adverse reactions and prognosis in the two groups were compared.Results There were no statistically significant differences in the intraoperative blood loss,operation time,CC grade and TNM staging between the two groups(all P>0.05).The incidences of anastomotic leakage,anastomotic bleeding,abdominal infection,and intestinal obstruction were similar between the two groups(all P>0.05).There were no significant differences in gastrointestinal reaction,bone marrow suppression and liver function damage between the two groups(all P>0.05).The local recurrence rate during 3 years after surgery in the treatment group significantly decreased(P<0.05).Conclusion Oxaliplatin combined with 5-Fluorouracil for HIPEC treatment of T4 CRC is safe,reliable,feasible,and beneficial to the prognosis of patients.

关 键 词：腹腔镜检查 结直肠肿瘤 腹腔热灌注化疗 

分 类 号：R735.34[医药卫生—肿瘤]