倍他米松磷酸钠的合成  

Synthesis of Betamethasone Sodium Phosphate

作　　者：马新成 王长斌 邓玉晓 赵思太 段崇刚 MA Xin-cheng;WANG Chang-bin;DENG Yu-xiao;ZHAO Si-tai;DUAN Chong-gang(Shandong Provincial Key Laboratory of Chemical Drugs,Shandong Academy of Pharmaceutical Sciences,Jinan 250101,China)

机构地区：[1]山东省药学科学院山东省化学药物重点实验室,山东济南250101

出　　处：《精细化工中间体》2022年第1期36-38,共3页Fine Chemical Intermediates

摘　　要：以9β,11β-环氧-16β-甲基孕甾-1,4-二烯-17α,21-二醇-3,20-二酮(DB11)为起始物料,经氟化、酯化、成盐得到倍他米松磷酸钠,总收率79.9%。产品结构经质谱、氢谱确证。工艺原料廉价易得,成本较低,适合工业化生产。Betamethasone sodium phosphate was prepared using 9β,11β-epoxy-16β-methylpregna-1,4-diene-17α,21-diol-3,20-dione(DB11) as starting material through a three-step process including fluorination,esterification and salt formation with a total yield of 79.9%.The raw materials in this process are cheap and easy to obtain,and the cost is low,which is suitable for industrial production.The product structure was confirmed by MS and1 H NMR.

关 键 词：倍他米松 倍他米松磷酸钠 合成 

分 类 号：R914[医药卫生—药物化学]