基于多数据库分析HLA-DPB1在肺腺癌中的潜在价值  

The potential value of HLA-DPB1 in lung adenocarcinoma was analyzed based on multi-database

作　　者：杨恒 张军 郭强 林称意 罗卫民 原野 程栋梁 罗湘玉 刘华 郭家龙 YANG Heng;ZHANG Jun;GUO Qiang(Department of Thoracic Cardiac and Great Vascular Surgery,Postgraduate Training Base,Shiyan Taihe Hospital,Jinzhou University of Medical Sciences,Shiyan Taihe Hospital,Hubei University of Medicine,Shiyan 442000,China)

机构地区：[1]锦州医科大学十堰市太和医院研究生培养基地十堰市太和医院(湖北医药学院附属医院)胸心大血管外科,442000

出　　处：《临床外科杂志》2022年第4期339-344,共6页Journal of Clinical Surgery

基　　金：2019湖北省卫生健康委科研立项资助项目(WJ2019F062)。

摘　　要：目的分析人类白细胞抗原(human leukocyte antigen,HLA)Ⅱ类抗原DPB1在肺腺癌(lung adenocarcinoma,LUAD)中的表达、肿瘤免疫浸润及其临床价值。方法利用Oncomine、Timer、UALCAN、GEPIA等数据库分析HLA-DPB1在LUAD病人中的表达、肿瘤免疫浸润及其临床价值。结果HLA-DPB1在LUAD组织中低表达,其表达水平与LUAD病人的临床病理特征和肿瘤蛋白53(tumor protein 53,Tp53)突变具有相关性(P<0.05),进一步分析可得到HLA-DPB1的表达下降与肺腺癌病人较差的预后显著相关(P<0.005)。HLA-DPB1的表达水平与LUAD免疫浸润纯度、免疫细胞(B细胞、CD8+T细胞、CD4+T细胞、巨噬细胞、树突状细胞和中性粒细胞)及其标志物水平有关。结论HLA-DPB1在LUAD组织中的表达水平降低,升高HLA-DPB1表达的LUAD病人倾向于更好的预后。HLA-DPB1的低表达与LUAD病人的免疫浸润细胞有关,提示HLA-DPB1有望成为LUAD病人预后生物标志物和免疫治疗的潜在靶点。Objective To analyze the expression,tumor immunoinvasion and clinical value of Human leukocyte antigen(HLA)class Ⅱ antigen DPB1 in Lung adenocarcinoma(LUAD)tissues.Methods Oncomine,TIMER,UALCAN,GEPIA and other databases were used to analyze the expression of HLA-DPB1 in LUAD patients,tumor immunoinvasion and its clinical value.Results HLA-DPB1 was low expressed in LUAD tissues,and its expression level was correlated with the clinicopathological characteristics and tumor protein 53(Tp53)mutation in LUAD patients(P<0.05).Further analysis showed that decreased HLA-DPB1 expression was significantly associated with poorer prognosis in patients with lung adenocarcinoma(P<0.005).The expression level of HLA-DPB1 was related to the purity of LUAD immunoinfiltrate,the level of immune cells(B cells,CD8+T cells,CD4+T cells,macrophages,dendritic cells and neutrophils)and their markers.Conclusion The expression level of HLA-DPB1 in LUAD tissues is decreased,and LUAD patients with elevated HLA-DPB1 expression tend to have a better prognosis.The low expression of HLA-DPB1 is associated with immunoinfiltrating cells in LUAD patients,suggesting that HLA-DPB1 is expected to be a prognostic biomarker and a potential target for immunotherapy in LUAD patients.

关 键 词：人类白细胞肮原-DPB1 肺腺癌 预后 免疫浸润 生物标志物 

分 类 号：R734.2[医药卫生—肿瘤]