Research Progress on Serum Porphyrin and Chronic Liver Disease  

作　　者：Xia Wang Yu Cai Weiqin Li Yuanyuan Jia Jiangfeng Fu Yaping Ni Kaige Liu 

机构地区：[1]Department of General Medicine,The First Affiliated Hospital of Xi'an Medical University,Xi'an 710000,China [2]Department of General Surgery,The First Affiliated Hospital of Xi'an Medical University,Xi'an 710000,China [3]Department of Neonatology,The First Affiliated Hospital of Xi'an Medical University Xi'an 710000,China [4]Faculty Development and Teaching Evaluation Office,The First Affiliated Hospital of Xi'an Medical University,Xi'an 710000,China [5]Department of Gastroenterology,The First Affiliated Hospital of Xi'an Medical University Xi'an 710000,China

出　　处：《Journal of Clinical and Nursing Research》2022年第3期221-228,共8页临床护理研究（英文）

基　　金：This study was supported by Key Research and Development Project of Shaanxi Science and Technology Department in 2022(Project No.:2022SF-577):Research on Correlation between Porphyrin and Chronic Liver Disease.

摘　　要：Liver cirrhosis is an important cause of chronic liver cancer.At present,a breakthrough has been achieved in the development of chronic hepatitis C treatment,but there is no effective measure to completely cure chronic hepatitis B.Porphyrins are a class of macromolecular heterocyclic compounds formed by interconnecting the a-carbon atoms of four pyrrole-like substituents through hypomethyl bonds.Porphyrins and their derivatives widely exist in organelles related to energy transfer in organisms.They are mainly involved in the synthesis of heme in human body.Heme is an iron-containing porphyrin compound,15-20% of which is synthesized and utilized in the liver.Studies have found that porphyrin metabolism disorder can occur in patients with chronic liver disease.The early stage of viral hepatitis is accompanied by increased production of porphyrins and their compounds,increased levels of peripheral circulating porphyrins,porphyrin cholestasis,and biochemical changes of free porphyrins which precede the histological changes.The accumulation of serum and liver protoporphyrins and the oxidative stress can cause liver and extrahepatic damage.On the one hand,porphyrin metabolism disorder can aggravate chronic liver disease,and even progress to liver cirrhosis and liver cancer.On the other hand,chronic liver disease can also aggravate porphyrin metabolism disorder,recurrent attacks,and damage to liver and extrahepatic tissues and organs.

关 键 词：Viral hepatitis Chronic hepatitis B HEMOGLOBIN PROTOPORPHYRIN PORPHYRIN 

分 类 号：O62[理学—有机化学]