不同剂量咖啡酸片联合重组人白细胞介素-11预防白血病化疗所致血小板减少症的效果  

Effects of different dose of caffeic acid tablets combined with rhIL-11 on prevention of chemotherapy-induced thrombocytopenia in leukemia patients

作　　者：林薇 朱海峰 李流娇[2] LIN Wei;ZHU Haifeng;LI Liujiao(Hematology Department,Zhaoqing First People’s Hospital;Transfusion Department,Zhaoqing First People’s Hospital,Zhaoqing,Guangdong 526000,China)

机构地区：[1]肇庆市第一人民医院血液科 [2]肇庆市第一人民医院输血科,广东肇庆526000

出　　处：《大医生》2022年第9期4-7,共4页Doctor

基　　金：肇庆市科技计划项目(编号:201904030733)。

摘　　要：目的探讨咖啡酸片联合重组人白细胞介素-11(rhIL-11)用于预防白血病化疗后血小板减少症的效果,为临床提供参考。方法选取2018年12月至2020年6月肇庆市第一人民医院收治的120例白血病患者为研究对象,按照随机数字表法分为观察1组、观察2组和对照组,各40例。观察1组和观察2组患者采用不同剂量的咖啡酸片联合rhIL-11治疗,对照组患者采用rhIL-11治疗,比较3组患者治疗后血小板减少症的发生率,血小板、白细胞、粒细胞、血红蛋白水平及不良反应发生率。结果观察1组、观察2组患者血小板减少症发生率显著低于对照组(P<0.05);3组患者治疗后7 d、14 d血小板、白细胞、粒细胞计数均低于治疗前,但观察1组、观察2组显著高于对照组,观察1组显著高于观察2组(P<0.05);3组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论使用不同剂量咖啡酸片联合rhIL-11相较于仅使用rhIL-11能够更有效预防血小板减少症,且在合理用药范围内作用其效果与咖啡酸剂量呈正相关。Objective To investigate the effect of caffeic acid tablets combined with recombinant human interleukin-11(rhIL-11)on the prevention of thrombocytopenia after chemotherapy for leukemia,and to provide clinical reference.Methods A total of 120 cases of leukemia patients in Zhaoqing First People’s Hospital from December 2018 to June 2020 were selected and randomly divided into observation group 1,observation group 2 and control group by random number table,with 40 cases in each group.Observation group 1 and observation group 2 were treated with caffeic acid tablets combined with rhIL-11 at different doses,while the control group was treated with rhIL-11.The incidence of thrombocytopenia in the three groups after treatment was compared,and the levels of platelets,white blood cells,granulocytes and hemoglobin in the three groups were observed before and after treatment.The incidence of adverse reactions was compared among the three groups.Results The incidence of thrombocytopenia in observation group 1 and observation group 2 was significantly lower than that in control group(P<0.05).Platelet count,white blood cell count and granulocyte count in 3 groups were lower than before 7 and 14 days after treatment,but observation group 1 and observation group 2 were significantly higher than control group,observation group 1 was significantly higher than observation group 2(P<0.05).There was no significant difference in the incidence of adverse reactions among 3 groups(P>0.05).Conclusion Compared with rhIL-11 alone,using different doses of caffeic acid tablets combined with rhIL-11 can more effectively prevent thrombocytopenia,and the effect within the scope of rational drug use is positively correlated with the dose of caffeic acid.

关 键 词：咖啡酸片 剂量 重组人白细胞介素-11 白血病 化疗 血小板减少症 

分 类 号：R733.7[医药卫生—肿瘤]