Antidepressant Effect of Shenwei Ningyu Tablets on Rat Chronic Stress Model and Mouse Tail Suspension Model  

作　　者：Yaxin WANG Shanshan GUO Yingjie GAO Ya TU Xiaolan CUI 

机构地区：[1]Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China [2]School of Acupuncture-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

出　　处：《Medicinal Plant》2022年第2期21-25,共5页药用植物：英文版

基　　金：National Major Scientific and Technological Special Project for"Significant New Drugs Development"(2019ZX09301-005).

摘　　要：[Objectives]To explore the antidepressant effect of Shenwei Ningyu Tablet,a new antidepressant traditional Chinese medicine,on rat chronic stress depression model and mouse tail suspension models.[Methods]Rat chronic stress model:except for the normal group,the rats in other groups were given corresponding chronic stress,and administered by gavage 1 h before modeling,for a total of 21 d.The changes of each indicator before and after the experiment were observed through the body weight change,the sugar water test,and open field test.The relevant hormone levels were detected by radioimmunoassay.Mouse tail suspension depression model:after continuous administration for 7 d,the activity times was recorded with the mouse automatic recorder,and the mouse immobility time was recorded after tail suspension,to explore the effects of each administration group on the tail suspension immobility time of mice.[Results]Chronic stress depression model:21 d after modeling,compared with the normal group,rats in the model group exhibited significantly reduced body weight,sucrose preference index,and horizontal and vertical movement scores(P<0.05).Compared with the model group,the low-dose Shenwei Ningyu Tablets group had significant differences in the sugar water test,horizontal and vertical movement scores(P<0.05).In addition,all three dose groups of Shenwei Ningyu Tablets could effectively reduce the content of CRF in chronic stress model rats,and the low dose group could significantly reduce the ACTH level in model rats(P<0.05).Mouse tail suspension depression model:the immobility time after tail suspension in each administration group was significantly different from that in the model group(P<0.05).[Conclusions]Shenwei Ningyu Tablets has a certain anti-depression effect on both the rat chronic stress depression model and the mouse tail suspension depression model.

关 键 词：Depression Rat chronic stress model Mouse tail suspension model Open field experiment Sugar water preference RADIOIMMUNOASSAY Shenwei Ningyu Tablets 

分 类 号：R74[医药卫生—神经病学与精神病学]