四子散外敷治疗胃肠动力功能障碍的Meta分析  

ShenqiDihuang DecoEffects of External Application of Sizi Powder in Treatment of Gastrointestinal Dysfunction:A Meta-Analysis

作　　者：杨燕贤 方培婉 陶杨 陈琳琳 YANG Yan-xian;FANG Pei-wan;TAO Yang;CHEN Lin-lin(Department of Gynecology,Shantou Hospital of Traditional Chinese Medicine Affliated to Guangzhou University of Chinese Medicine,Shantou Guanglong 515031;School of Medicine,Foshan University,Foshan Guanglong 528000)

机构地区：[1]广州中医药大学附属汕头中医院妇科,广东汕头515031 [2]佛山科学技术学院医学院,广东佛山528000

出　　处：《世界中西医结合杂志》2022年第4期670-676,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：汕头市科技计划医疗卫生类别项目(180806214012305)。

摘　　要：目的分析和评价四子散外敷对胃肠功能障碍(Gastrointestinal Dysfunction)的治疗效果及有效性。方法制定纳入和排除标准,制定文献检索策略,采用计算机检索Pubmed、中国知网(CNKI)、中国科技期刊全文数据库(VIP)、万方数据库(WANFANG DATE)和中国生物医学文献数据库(CBM),查找各大数据库中有关应用四子散外敷治疗胃肠功能障碍的相关文献。对检索文献进行筛选及质量评价,使用RevMan 5.3进行数据分析和风险偏倚评估。结果最终纳入14项研究,共1081例病例。Meta分析结果显示,加用四子散外敷相比常规治疗可缩短排气时间(SMD=-1,23,95%CI(-1.20,-1.00);Z=10.75;P<0.00001)和排便时间(SMD=-1.17,95%CI(-1.36,-0.97);Z=4.84;P<0.00001),可缓解腹胀程度(SMD=-0.76,95%CI(-1.08,-0.44);Z=4.63;P<0.00001),Meta分析结果显示,加用四子散外敷可提高缓解便秘疗效(RR=1.42,95%CI(1.30,1.55);Z=7.98;P<0.00001),可提高消除腹胀疗效(RR=1.48,95%CI(1.26,1.75);Z=4.66;P<0.00001)及临床疗效(RR=1.32,95%CI(1.19,1.47);Z=5.18;P<0.00001)。结论现有临床资料表明加用四子散外敷对胃肠动力功能障碍的疗效优于常规治疗,值得临床推广。但由于纳入文献质量总体不高,上述结论有待临床上设计严谨的高质量、大样本、多中心的临床随机试验进一步验证。Objective To analyze and evaluate the therapeutic effects and effectiveness of the external application of Sizi Powder on gastrointestinal dysfunction.Methods Inclusion and exclusion criteria,as well as a literature retrieval strategy were developed.PubMed,CNKI,VIP,Wanfang Data,and CBM were searched for research articles on the external application of Sizi Powder in the treatment of gastrointestinal dysfunction.The articles were screened out and evaluated.Data analysis and risk of bias assessment were performed using RevMan 5.3.Results Fourteenresearch articles were included,involving 1081 cases.Meta-analysis results showed compared with the conventional treatment alone,external application of Sizi Powder based on conventional treatment could shorten the evacuationtime[SMD=-1.23,95%CI(-1.20,-1.00);Z=10.75;P<0.00001]and defecation time[SMD=-1.17,95%CI(-1.36,-0.97);Z=4.84;P<0.00001]and relieve abdominal distension[SMD=-0.76,95%CI(-1.08,-0.44);Z=4.63;P<0.00001].Moreover,the combined treatment could also alleviate constipation(RR=1.42,95%CI(1.30,1.55);Z=7.98;P<0.00001),eliminate abdominal distension(RR=1.48,95%CI(1.26,1.75);Z=4.66;P<0.00001),and improve clinical efficacy(RR=1.32,95%CI(1.19,1.47);Z=5.18;P<0.00001).Conclusion The existing clinical data indicate that the external application of Sizi Powder is superior to conventional treatment for gastrointestinal dysfunction,and it is worthy of clinical promotion.However,due to the low quality of the included articles,the above conclusion needs to be further verified by well-designed,high-quality,large-sample,multi-center randomized clinical trials.

关 键 词：胃肠功能障碍 胃肠功能 四子散 META分析 

分 类 号：R573[医药卫生—消化系统] R574[医药卫生—内科学]