CBX4和NET1在结肠癌中的表达及临床意义  

Expressions and clinical significance of CBX4 and NET1 in colon cancer

作　　者：李冰 闫江鹤 朱凤池 王作醒 吴记先 赵秀娟 陈苗凤 LI Bing;YAN Jiang-he;ZHU Feng-chi;WANG Zuo-xing;WU Ji-xian;ZHAO Xiu-juan;CHEN Miao-feng(Department of Anorectal,Baoding Fourth Central Hospital,Baoding 072350,China;Department of General Surgery,Baoding Fourth Central Hospital,Baoding 072350,China;Department of Sensory Management,Baoding Fourth Central Hospital,Baoding 072350,China;Department of Anorectal,Baoding Second Hospital,Baoding 071051,China)

机构地区：[1]保定市第四中心医院肛肠科,河北保定072350 [2]保定市第四中心医院普外科,河北保定072350 [3]保定市第四中心医院感染管理科,河北保定072350 [4]保定市第二医院肛肠科,河北保定071051

出　　处：《中国现代普通外科进展》2022年第4期287-291,共5页Chinese Journal of Current Advances in General Surgery

基　　金：河北省医学科学研究课题计划项目(20191872)。

摘　　要：目的:探究色素框同源物4(CBX4)和神经上皮细胞转化基因1(NET1)蛋白与结肠癌患者临床病理特征及预后关系及意义。方法:取2012年8月至2015年2月97例结肠癌患者结肠癌组织及癌旁组织(距病灶>5 cm),免疫组织化学染色法检测CBX4、NET1蛋白表达水平,患者随访5年,分析CBX4、NET1蛋白表达与患者临床病理特征及预后关系。结果:结肠癌组织中CBX4、NET1蛋白阳性表达率均显著高于癌旁组织(P均<0.05)。低分化、T3~T4浸润深度、TNM分期Ⅲ期和有淋巴结转移患者结肠癌组织中CBX4、NET1蛋白阳性表达率均显著高于高中分化、T1~T2浸润深度、TNM分期Ⅰ~Ⅱ期和无淋巴结转移患者(P均<0.05)。CBX4、NET1阳性表达组患者5年总生存率明显低于CBX4、NET1阴性表达组患者(P均<0.05)。T3~T4浸润深度、TNM分期Ⅲ期、淋巴结转移、CBX4阳性表达、NET1阳性表达是结肠癌患者不良预后的独立危险因素(P均<0.05)。结论:与癌旁组织相比,结肠癌组织中CBX4、NET1蛋白阳性表达率显著升高,与肿瘤分化程度、浸润深度、TNM分期、淋巴结转移及患者5年总生存率有关,可能作为结肠癌预后标志物,在患者预后评估方面有一定价值。Objective:To explore the relationships between Chromobox homolog 4(CBX4),Neuroepithelial cell transforming gene 1(NET1)proteins and clinicopathological characteristics,prognosis of colon cancer patients and its significance.Methods:97 patients with colon cancer admitted to Baoding fourth central hospital and Baoding second hospital from August 2012 to February 2015 were selected as the study subjects,colon cancer tissues and adjacent tissues(more than 5 cm away from the focus)were collected during operation.Immunohistochemical staining was used to detect the expressions of CBX4 and NET1.The patients were followed up for 5 years.The relationships between the expressions of CBX4,NET1 and clinicopathological characteristics,prognosis were analyzed.Results:The positive expression rates of CBX4 and NET1 proteins in colon cancer tissues were significantly higher than those in adjacent tissues(P<0.05).The positive expression rates of CBX4 and NET1 proteins in low differentiation,T3-T4 invasion depth,TNM stage III and lymph node metastasis patients were significantly higher than those in high differentiation,T1-T2 invasion depth,TNM stage I-II and non-lymph node metastasis patients(P<0.05).The 5-year overall survival rate of patients with positive expressions of CBX4 and NET1 was significantly lower than that of patients with negative expressions of CBX4 and NET1(P<0.05).The depth of T3-T4 invasion,TNM stage III,lymph node metastasis,positive expressions of CBX4 and NET1 were independent risk factors for poor prognosis of patients with colon cancer(all P<0.05).Conclusion:Compared with the adjacent tissues,the positive expression rates of CBX4 and NET1 proteins in colon cancer tissues are significantly higher,it is related to the degree of differentiation,depth of invasion,TNM stage,lymph node metastasis and 5-year overall survival rate of patients,and may be a prognostic marker of colon cancer,which has a certain value in clinical and prognostic evaluation of patients.

关 键 词：色素框同源物4 神经上皮细胞转化基因1 结肠癌 基因表达 

分 类 号：R735.35[医药卫生—肿瘤]