Formulation,in-vitro Evaluation and Dissolution Enhancement of Griseofulvin by Solid Dispersion Method  

作　　者：Gopal Pokhrel Bikash Dani Srijana Shrestha Rakshya Chaudhary Ramesh Dhami Barnabas Sunuwar Sharad Pudasaini Vijay Yadav Lalit Mohan Pant Rajan Ghimire 

机构地区：[1]Department of Pharmacy,Karnali College of Health Sciences,Kathmandu,Nepal [2]Department of Pharmacy,HOPE International College,Lalitpur,Nepal [3]Deurali-Janta Pharmaceuticals Pvt.Ltd.,Kathmandu,Nepal

出　　处：《Journal of Pharmacy and Pharmacology》2022年第4期125-131,共7页药剂与药理学（英文版）

基　　金：This research received no specific grant from any funding agency in public,commercial,or not-for-profit sectors.

摘　　要：Introduction:Griseofulvin is an antifungal drug belonging to Biopharmaceutical Classification System(BCS class II)having low solubility.Objectives:To formulate,evaluate and enhance the dissolution of poorly water soluble drug Griseofulvin by using solid dispersion method.Methods:Six formulations were prepared by solid dispersion method using Polyethylene Glycol(PEG 6000)125 mg,0 mg,62.5 mg,100 mg,25 mg,150 mg and superdisintegrants Crospovidone 0 mg,125 mg,62.5 mg,100 mg,25 mg,150 mg in all batches respectively.Findings:Satisfactory results were obtained from evaluation of physical characteristics of Griseofulvin tablets including:carr’s compressibility index(17.5±0.19%to 11.76±0.67%),Hausner ratio(1.21±0.01 to 1.13±0.02)and post compression parameters including:thickness(5.16±0.02 mm to 4.57±0.19 mm),friability(0.024%to 0.322%),hardness(4±0.28 kg/cm^(2)to 5±0.57 kg/cm^(2)),disintegration time(14-870 seconds).Conclusions:F3 was best formulation among all formulated batches with in-vitro drug release 30.05%in 10 minutes,69.21%in 30 minutes and 97.11%in 45 minutes.This indicated that formulation F3 batch with PEG 6000 of 62.5 mg and crospovidone 62.5 mg showed increased dissolution.

关 键 词：GRISEOFULVIN FORMULATION solid dispersion SOLUBILITY EVALUATION 

分 类 号：TG1[金属学及工艺—金属学]