基于文献回顾的肠道菌群失调疾病-证候分布规律研究  

Study on Disease-Syndrome Distribution Law of Intestinal Flora Imbalance Based on Literature Review

作　　者：单心觉 孙肇阳 周鹏[1] 谢伟[1] SHAN Xin-jue;SUN Zhao-yang;ZHOU Peng;XIE Wei(Chinese Medicinal College,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中医学院,天津301617

出　　处：《中国中医基础医学杂志》2022年第4期571-574,662,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点研发计划项目(2018YFC1706801)-辨证保健理论研究与中药复方保健产品研发平台整合研究;中国工程院咨询研究项目(2018-ZD-001)-整合医学理论与实践若干战略问题研究-中医与西医的整合;国家中医药管理局中医药行业科研专项课题(201107006)-中医慢病临床科研体系及其成果转化应用模式研究;天津市教委课题(2018KJ042)-基于AMPK-PPARɑ-SCAD通路探讨芪参益气滴丸改善冠心病冬眠心肌能量代谢的机制研究;天津中医药大学校级课题(XJ201801)-中医“治未病”理论与辨识应用研究。

摘　　要：目的:分析肠道菌群失调的相关疾病与中医证候,研究其病-证分布规律。方法:采用文献回顾研究,纳入近10年有关肠道菌群失调中医证候的临床研究文献,提取疾病、证候、证素等关键信息,建立疾病-证候数据库。结果:提取出肠道菌群失调相关疾病20种,中医证候15种,病位证素7种,病性证素12种,相关疾病主要见于溃疡性结肠炎、消化性溃疡、肠易激综合征等。排名前5位的证候为肝郁脾虚证、脾胃虚弱证、脾肾阳虚证、寒湿困阻证、肠道湿热证。证素分析显示,主要病位为脾、肝、胃、肾、大肠、胆、心,以脾为首,主要病性是气虚、湿、气滞、热、阳虚、寒、痰、阴虚、血瘀、毒、火、血虚,以气虚为最。结论:本文对于肠道菌群失调的疾病-证候分布规律研究,可为肠道菌群失调人群中医药诊疗方案的制定及日常保健调理等提供有益的参考。Objective:To research the TCM syndromes and the related diseases of intestinal flora imbalanceand to study their distribution.Methods:Clinical research literature about the TCM syndromes of intestinal flora imbalance for the past ten years was retrospectively included.Then relevant information such as disease,syndromes and so on was screened and extracted.The database of disease and TCM syndrome was established.Results:Finally,20 related diseases,15 TCM syndrome types,7 disease location syndromes,and 12 disease syndromes were extracted.The main disease were ulcerative colitis,peptic ulcer,irritablebowel and so on.The top 5types of syndromes were liver stagnation and spleen deficiency syndrome,spleen and stomach weakness syndrome,spleen and kidney deficiency syndrome,cold and dampness and obstructionsyndrome,intestinal dampness and heat syndrome.The disease location syndromes included spleen,liver,stomach,kidney,large intestine,gallbladder and heart.The major was spleen.The disease syndromes included Qi-deficiency,dampness,Qi-stagnation,heat,Yang-deficiency,cold,phlegm,Yin-deficiency,blood stasis,virulent,fire,and blood-deficiency.The major was Qi-deficiency.Conclusions:Studying on disease and TCM syndrome distribution of intestinal flora imbalance,will provide useful reference for the treatment plan and the daily health careof intestinal flora imbalancein TCM.

关 键 词：肠道菌群失调 中医证候 文献回顾 

分 类 号：R228[医药卫生—中医基础理论] R574[医药卫生—中医学]