血管内皮生长因子水平对2型糖尿病患者并发视网膜微血管病变的预测价值  

Predictive value of vascular endothelial growth factor level in patients with type 2 diabetes mellitus complicated with retinal microangiopathy

作　　者：李继红 牛梦琦 LI Jihong;NIU Mengqi(Department of Health Medicine,the 909th Hospital of Joint Logistic Support Force(Southeast Hospital affiliated to Xiamen University),Zhangzhou 363000,China)

机构地区：[1]联勤保障部队第九〇九医院(厦门大学附属东南医院)健康医学科,福建漳州363000

出　　处：《实用医学杂志》2022年第8期1001-1005,共5页The Journal of Practical Medicine

摘　　要：目的探讨血管内皮生长因子水平(VEGF)对2型糖尿病(T2DM)患者并发视网膜微血管病变(diabetic retinopathy,DR)的预测价值。方法选择2018年7月至2021年3月在我院就诊的T2DM患者146例作为研究对象,根据是否发生DR分为DR组(n=67)和非DR组(n=79)。单因素及多因素Cox回归分析影响T2DM患者并发DR的因素;根据独立影响因素构建列线图预测模型,并评价其预测效能。结果DR组患者T2DM病程明显久于非DR组(P<0.05),在生化指标方面,DR组患者FPG、HbA1c、GA、Scr、UA、BUN、UACR以及VEGF明显高于非DR组(P<0.05),而ALB和RBC明显低于非DR组,差异均有统计学意义(P<0.05)。T2DM病程、HbA1c、UA、VEGF是T2DM患者发生DR的独立危险因素(P<0.05),ALB和RBC是保护因素(P<0.05)。依据危险因素构建的预测模型的ROC曲线下面积(AUC)为0.874(95%CI:0.825~0.928,P<0.001),具有较高的预测价值。结论VEGF水平在DR患者血清中显著升高,是T2DM患者并发DR的独立危险因素,对DR具有较高的预测价值。Objective To investigate the predictive value of vascular endothelial growth factor(VEGF)level in patients with type 2 diabetes mellitus(T2DM)complicated with retinal microangiopathy.Methods A total of 146 patients with T2DM treated in our hospital from July 2018 to March 2021 were selected and were divided into DR group(n=67)and non-DR group(n=79).Univariate and multivariate Cox regression analysis of the factors affecting T2DM patients with DR;The nomogram prediction model is constructed according to the independent influencing factors,and its prediction efficiency is evaluated.Results The course of T2DM in DR group was significantly longer than that in non-DR group(P<0.05).In terms of biochemical indexes,FPG,HbA1c,GA,SCR,UA,bun,UACR and VEGF in DR group were significantly higher than those in non DR group(P<0.05),while ALB and RBC were significantly lower than those in non DR group(P<0.05).The course of T2DM,HbA1c,UA and VEGF were independent risk factors for DR in T2DM patients(P<0.05),ALB and RBC were protective factors(P<0.05).The area under ROC curve(AUC)of the prediction model constructed according to risk factors was 0.874(95%CI:0.825~0.928,P<0.001),which had high prediction value.Conclusion The level of VEGF was significantly increased in the serum of DR patients,which could be an independent risk factor for T2DM patients with DR and has a high predictive value for DR.

关 键 词：血管内皮生长因子 2型糖尿病 视网膜微血管病变 危险因素 

分 类 号：R783.1[医药卫生—口腔医学]