xSPECT Quant联合唾液腺显像评估分化型甲状腺癌甲状腺全切术后^(131)I治疗前患者腮腺和残留甲状腺功能  

xSPECT Quant combined with salivary gland scintigraphy for evaluating parotid gland function and residual thyroid gland in differentiated thyroid carcinoma patients after total thyroidectomy and before^(131)I treatment

作　　者：尚康康 闫志华[1] 杜晓光[1] 周会 程兵[1] SHANG Kangkang;YAN Zhihua;DU Xiaoguang;ZHOU Hui;CHENG Bing(Department of Nuclear Medicine,the First Affiliated Hospital of Zhengzhou University,Henan Medical Key Laboratory of Molecular Imaging,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院核医学科河南省分子影像医学重点实验室,河南郑州450052

出　　处：《中国医学影像技术》2022年第5期663-668,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察xSPECT Quant联合唾液腺显像(SGS)评估分化型甲状腺癌(DTC)甲状腺全切术后^(131)I治疗前患者腮腺和残留甲状腺功能的价值。方法前瞻性纳入60例拟接受^(131)I治疗的甲状腺全切术后DTC患者,于^(131)I治疗前日行头颈部xSPECT Quant断层融合显像及SGS,计算左、右侧及整体腮腺摄取指数(UI)、最大排泌率(MSR)、最大标准摄取值(SUV_(max))、平均标准摄取值(SUV_(mean))及残留甲状腺SUV_(max)、SUV_(mean);根据xSPECT Quant断层图像中颈部存在残留甲状腺组织与否将患者分为残留组(n=32)和无残留组(n=28),依照参数分析法评估腮腺功能结果而分为功能正常组(n=43)和功能受损组(n=17);观察xSPECT Quant联合SGS评估腮腺和残留甲状腺功能的价值。结果功能正常组与功能受损组左、右侧腮腺UI及SUV_(mean)差异均有统计学意义(P均<0.05),腮腺整体UI与SUV_(max),MSR与SUV_(max)、SUV_(mean)均呈低度相关(r=0.356、0.327、0.380,P均<0.01),而UI与SUV_(mean)呈中度相关(r=0.531,P<0.01)。残留组与无残留组24 h摄碘率差异有统计学意义(P<0.05),且残留甲状腺SUV_(max)与24 h摄碘率呈低度相关(r=0.381,P<0.05)。结论xSPECT Quant联合SGS对评估DTC甲状腺全切术后^(131)I治疗前患者腮腺和残留甲状腺功能具有一定价值,可初步筛查腮腺功能障碍并评估残留甲状腺的摄碘能力。Objective To observe the value of xSPECT Quant combined with salivary gland scintigraphy(SGS)for evaluating parotid gland function and residual thyroid gland in patients with differentiated thyroid carcinoma(DTC)after total thyroidectomy and before ^(131)I treatment.Methods Totally 60 DTC patients after total thyroidectomy who would underwent ^(131)I treatment were prospectively enrolled.Head and neck xSPECT Quant tomographic fusion imaging and SGS were performed the day before ^(131)I treatment.The uptake index(UI),maximum excretion rate(MSR),maximum standard uptake value(SUV_(max)),mean standard uptake value(SUV_(mean))of left,right and whole parotid glands,as well as SUV_(max)and SUV_(mean)of the residual thyroid were calculated.The patients were divided into residual group(n=32)and non-residual group(n=28)according to whether with or without residual thyroid tissue on xSPECT Quant tomographic images,also into normal function group(n=43)and impaired function group(n=17)according to results of parametric analysis for parotid gland function.The value of xSPECT Quant combined with SGS for evaluating parotid gland function and residual thyroid gland was evaluated.Results Significant differences of UI and SUV_(mean)of left and right parotid gland were found between normal function group and impaired function group(all P<0.05).There were low correlations between UI and SUV_(max)of whole parotid gland,as well as between MSR and SUV_(max),SUV_(mean)(r=0.356,0.327,0.380,all P<0.01),while UI was moderately correlated with SUV_(mean)(r=0.531,P<0.01).Significant difference of 24 h iodine uptake rate was detected between residual group and non-residual group(P<0.05),while SUV_(max)of residual thyroid gland was lowly correlated with 24 h iodine uptake rate(r=0.381,P<0.05).Conclusion xSPECT Quant combined with SGS had certain value for evaluating parotid gland the function and residual thyroid gland in DTC patients after total thyroidectomy before ^(131)I treatment,which could not only initially screen parotid gland dysfunct

关 键 词：甲状腺肿瘤 碘同位素 放射性核素显像 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 

分 类 号：R736.1[医药卫生—肿瘤] R817.8[医药卫生—临床医学]