焦亡与缺血性脑卒中关系的研究进展  

Research progress on the relationship between pyroptosis and ischemic stroke

作　　者：鲁明[1] 郭帅 刘恒兴[1] LU Ming;GUO Shuai;LIU Hengxing(Department of Human Anatomy and Histoembryology,Xinxiang Medical University,Henan,Xinxiang 453000,China;Laboratory of Human Anatomy,Sanquan College of Xinxiang Medical University,Henan,Xinxiang 453000,China)

机构地区：[1]新乡医学院人体解剖学与组织胚胎学系,河南新乡453000 [2]新乡医学院三全学院人体解剖学实验室,河南新乡453000

出　　处：《中国医药科学》2022年第8期60-63,共4页China Medicine And Pharmacy

摘　　要：焦亡是一种炎症类型的程序性细胞死亡方式,发生于炎症小体激活后。焦亡直接由最近发现的一个被称为Gasdermin(GSDM)的成孔蛋白家族调节,其最具特征的是Gasdermin D(GSDMD)。最近的研究表明焦亡与多种神经系统病变的发病机制有关,尤其在缺血性脑卒中的病理发展中,焦亡有广泛的参与。本文主要讨论诱发焦亡的分子机制和发生缺血性脑卒中时焦亡的分子靶点,以期为缺血性脑卒中后脑损伤的治疗及预后提供新的策略。Pyroptosis is a type of inflammatory programmed cell death that occurs after the activation of inflammasome.Pyroptosis is directly regulated by a recently discovered pore-forming protein family called gasdermin(GSDM),the most characteristic of which is gasdermin D(GSDMD).Recent studies have shown that pyroptosis is related to the pathogenesis of a variety of nervous system diseases,especially the ischemic stroke.This paper mainly discusses the molecular mechanism of inducing pyroptosis and the molecular targets of pyroptosis in ischemic stroke,in order to provide a new strategy for the treatment and prognosis of brain injury after ischemic stroke.

关 键 词：焦亡 炎症小体 Gasdermin D 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]