血清肠脂肪酸结合蛋白联合多层螺旋CTA诊断急性缺血性肠病价值的研究  

Study on the value of serum intestinal fatty acid binding protein combined with multi-layer spiral CTA in the diagnosis of acute ischemic bowel disease

作　　者：张伟伟[1] 黄炎东 王家旭 唐少波[1] ZHANG Weiwei;HUANG Yandong;WANG Jiaxu;TANG Shaobo(Gastroenterology Department,the First People’s Hospital of Nanning,Guangxi,Nanning 530000,China)

机构地区：[1]南宁市第一人民医院消化内科,广西南宁530000

出　　处：《中国医药科学》2022年第9期169-172,191,共5页China Medicine And Pharmacy

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z2015277)。

摘　　要：目的通过比较急性缺血性肠病与非急性缺血性肠病患者血清肠脂肪酸结合蛋白(I-FABP)及多层螺旋CT血管造影(MSCTA)的影像特征,分析两者之间的相关性、比较两者对急性缺血性肠病的诊断效能。方法选取南宁市第一人民医院2015年3月至2020年12月的急性腹痛患者65例,其中30例急性缺血性肠病的患者为观察组,另外35例非急性缺血性肠病患者为对照组,比较血清I-FABP与MSCTA评分对急性缺血性肠病诊断效能的高低并探究两者联合的诊断效能。结果观察组血清I-FABP水平及MSCTA评分均高于对照组,差异有统计学意义(P<0.05);血清I-FABP水平及MSCTA评分均对急性缺血性肠病诊断有影响(P<0.05);血清I-FABP水平诊断急性缺血性肠病的截断值为125.65 g/L,MSCTA评分诊断急性缺血性肠病的截断值为2.5分,血清I-FABP水平、MSCTA评分、联合检测诊断急性缺血性肠病的ROC曲线下面积分别为0.880、0.761、0.885;联合检测较MSCTA评分诊断效能高(P<0.05)。结论血清I-FABP检测联合MSCTA有助于提高急性缺血性肠病的诊断效能。Objective By comparing the imaging characteristics of serum intestinal fatty acid binding protein(I-FABP)and multi-slice spiral CT angiography(MSCTA)in patients with acute ischemic bowel disease and nonacute ischemic bowel disease,the correlation between the two was analyzed and the diagnostic efficacy of the two was compared.Methods A total of 65 patients with acute abdominal pain in the First People’s Hospital of Nanning from March 2015 to December 2020 were selected.Among them,30 patients with acute ischemic bowel disease were in the observation group,and the other 35 patients with non-acute ischemic bowel disease were in the control group.Compare the diagnostic efficacy of serum I-FABP and MSCTA scores for acute ischemic bowel disease,explore the combined diagnostic efficacy of the two,and analyze their prognostic predictive ability for acute ischemic bowel disease.Results The serum I-FABP level and MSCTA score of the observation group were higher than those of the control group,and this differences were statistically significant(P<0.05);both serum I-FABP level and MSCTA score had an impact on the diagnosis of acute ischemic bowel disease,and this differences were statistically significant(P<0.05).The cut-off value of serum I-FABP level for the diagnosis of acute ischemic bowel disease was 125.65 g/L,the cut-off value of MSCTA score for the diagnosis of acute ischemic bowel disease was 2.5 points.The serum I-FABP level,MSCTA score,and combined detection of the area under the ROC curve for the diagnosis of acute ischemic bowel disease were 0.880,0.761,and 0.885,respectively.The combined detection of acute ischemic bowel disease was higher than the MSCTA score diagnosis efficiency,the difference have statistical significance(P<0.05).Conclusion The detection of serum I-FABP combined with MSCTA can help to improve the diagnostic efficiency of acute ischemic bowel disease.

关 键 词：肠脂肪酸结合蛋白 多层螺旋CT血管造影 急性缺血性肠病 诊断 

分 类 号：R574[医药卫生—消化系统]