中国皮肤黑色素瘤疾病负担研究  

Analysis of disease burden of skin malignant melanoma in China

作　　者：王燕[1] 肖生祥[1] 张燕飞[1] WANG Yan;XIAO Shengxiang;ZHANG Yanfei(Department of Dermatology,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,P.R.China)

机构地区：[1]西安交通大学第二附属医院,西安710004

出　　处：《中国循证医学杂志》2022年第5期524-529,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金项目(编号:81703129)。

摘　　要：目的分析全球疾病负担(GBD 2019)数据库的中国皮肤黑色素瘤数据,探讨中国皮肤黑色素瘤疾病流行病学负担及变化趋势。方法检索GBD 2019数据库中国皮肤黑色素瘤的患病数/率、发病数/率、伤残调整生命年(DALY)/DALY率、死亡数/率及中国和全球的社会人口学指数(SDI值),分析中国1990年至2019年皮肤黑色素瘤的流行趋势及年龄、时期、出生队列趋势,并研究皮肤黑色素瘤发病率与SDI之间的关系。结果2019年,中国皮肤黑色素瘤年龄标准化患病率及年龄标准化发病率均位于全球偏低水平,年龄标准化死亡率位于第35位(GBD 204个国家),患病人数及发病人数较1990年增长12.65%和3.57%,患病率、发病率呈缓慢持续上升,DALY率与死亡率下降。中国皮肤黑色素瘤患病年龄以50~54岁为界,呈现先升高后降低的趋势,男性发病人数峰值年龄晚于女性(男性55~59岁,女性50~54岁),但男性死亡人数高峰年龄出现早于女性(男性55~59岁,女性75~79岁)。随着SDI增加,中国皮肤黑色素瘤的年龄标准化发病率呈线性上升趋势,DALY率与SDI负相关(P<0.05)。结论1990年至2019年间,中国皮肤黑色素瘤的流行病学长期变化趋势显示年龄标准化发病率与患病率呈上升趋势,DALY与死亡率呈下降趋势,与中国社会、医疗水平发展相关。Objective To analyze the epidemiological burden and trend of skin malignant melanoma in China based on the data from the global burden of disease 2019(GBD 2019).Methods The data about quantity of incidences/illnesses/deaths,age-standardized incidence/prevalence rates/mortality,disability-adjusted life years(DALYs),and DALY rate of skin malignant melanoma in China from 1990 to 2019 were obtained from the GBD 2019 databases.The epidemiological trends,age-period-cohort trends,and the relationship between the incidence and sociodemographic index(SDI)were analyzed.Results In 2019,both prevalence and incidence of skin malignant melanoma in China were at low levels in the world,the age-standardized mortality ranked the 35th in the 204 countries GBD researched,the number of prevalent cases and incident cases increased compared with 1990(12.65%and 3.57%,respectively),the prevalence and incidence rates showed growth trends,while the DALY rate and mortality decreased slowly.The prevalence of skin malignant melanoma peaked age at 50 to 54 years old.The incidence peak age of males was older than that of females(55-59 years old for males vs.50-54 years old for females),while the mortality peak age of males was younger than that of females(55-59 years old for males vs.75-79 years old for females).With the increasing of SDI value,the incidence of skin malignant melanoma showed a linear growth trend.DALY rate was negatively correlated with SDI(P<0.05).Conclusion From 1990 to 2019,age-standardized incidence and prevalence of skin malignant melanoma in China are increasing,while DALY rate and mortality are decreasing,and these are correlated with social and medical development.

关 键 词：全球疾病负担2019 中国 皮肤黑色素瘤 负担 

分 类 号：R739.5[医药卫生—肿瘤]