福建省甲状腺功能正常成人血清碘医学参考值范围的建立  

Establishment of a medical reference range of serum iodine in adults with normal thyroid function in Fujian Province

作　　者：吴晓燕[1] 陈志辉[1] 吴佳妮[1] 王木华[1] Wu Xiaoyan;Chen Zhihui;Wu Jiani;Wang Muhua(Department of Endemic Disease,Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,China)

机构地区：[1]福建省疾病预防控制中心地方病防治研究室,福州350001

出　　处：《中华地方病学杂志》2022年第3期186-188,共3页Chinese Journal of Endemiology

基　　金：福建省科技厅自然科学基金(2018J01120);2019年福建省科技创新平台建设项目(2019Y2001)。

摘　　要：目的建立福建省甲状腺功能(简称甲功)正常成人血清碘医学参考值范围。方法2019年9月至2020年1月,在福建省碘适宜的3个地区选取年龄为16~60岁且在当地生活5年及以上的常住人口作为调查对象。采集尿样、血样,检测尿碘、血清碘以及甲功指标[促甲状腺激素(TSH)、甲状腺球蛋白(Tg)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、总三碘甲状腺原氨酸(TT_(3))、总甲状腺素(TT_(4))、甲状腺过氧化物酶抗体(TPOAb)以及甲状腺球蛋白抗体(TgAb)]水平。采用百分位数法建立甲功正常成人血清碘95%医学参考值范围,并采用Pearson相关分析进行甲功正常成人血清碘与甲功指标的相关性分析。结果共检测149例甲功正常成人,尿碘中位数为119.45μg/L,处于碘适宜水平(100~199μg/L);血清碘为(61.35±16.20)μg/L,甲功正常成人血清碘95%医学参考值范围初步定为34.36~97.17μg/L。相关性分析显示,血清碘与FT_(4)水平呈正相关(r=0.17,P=0.035),与其余甲功指标均未见相关性(P均>0.05)。结论成功建立了福建省甲功正常成人血清碘医学参考值范围,为成人个体碘营养情况判断提供了依据。Objective To establish a medical reference range of serum iodine in adults with normal thyroid function in Fujian Province.Methods Permanent residents aged 16-60 years old and living in the local area for 5 years and more were selected as survey subjects in three areas with appropriate iodine nutrition in Fujian Province from September 2019 to January 2020.Urine and blood samples were collected to detect urinary iodine,serum iodine and thyroid function indexes[thyroid stimulating hormone(TSH),thyroglobulin(Tg),free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),total triiodothyronine(TT_(3)),total thyroxine(TT_(4)),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)]levels.The percentile method was used to establish the 95%medical reference range of serum iodine in adults with normal thyroid function,and Pearson correlation analysis was used to analyze the correlation between serum iodine and thyroid function indexes in adults with normal thyroid function.Results A total of 149 adults with normal thyroid function were examined,and the median urinary iodine was 119.45μg/L,which was at the appropriate level(100-199μg/L);serum iodine was(61.35±16.20)μg/L,and the 95%medical reference range of serum iodine in adults with normal thyroid function was preliminarily formulated as 34.36-97.17μg/L.Correlation analysis showed that serum iodine was positively correlated with FT_(4)level(r=0.17,P=0.035),but was not correlated with other thyroid function indexes(P>0.05).Conclusion The medical reference range of serum iodine in adults with normal thyroid function in Fujian Province is successfully established,which provides a basis for judgment of individual iodine nutrition in adults.

关 键 词：血清 碘 成人 参考值 

分 类 号：R151.42[医药卫生—营养与食品卫生学]