福建省不同区域8~10岁儿童及孕妇尿碘、盐碘、甲状腺结节间的相关关系  

Correlation between urinary iodine,salt iodine,and thyroid nodules in children aged 8-10 years and pregnant women in different regions of Fujian Province

作　　者：王木华[1] 蔡昕仪 陈志辉[1] 陈迪群[1] 王丽金 郑欣怡 吴佳妮[1] 兰莺 吴晓燕[1] 何萌[1] Wang Muhua;Cai Xinyi;Chen Zhihui;Chen Diqun;Wang Lijin;Zheng Xinyi;Wu Jiani;Lan Ying;Wu Xiaoyan;He Meng(Department of Endemic Disease,Center for Disease Control and Prevention of Fujian Province,Fuzhou 350001,China;School of Public Health,Fujian Medical University,Fuzhou 350004,China)

机构地区：[1]福建省疾病预防控制中心地方病防治研究室,福州350001 [2]福建医科大学公共卫生学院,福州350004

出　　处：《中华地方病学杂志》2022年第3期209-215,共7页Chinese Journal of Endemiology

基　　金：福建省科技厅自然科学基金(2018J01120);2019年福建省科技创新平台建设项目(2019Y2001)。

摘　　要：目的了解福建省不同区域8~10岁儿童及孕妇尿碘、盐碘、甲状腺结节间的相关关系,初步探讨甲状腺疾病的影响因素。方法2019年9-11月采用横断面研究方法,选择福建省东山县和平潭县作为调查点。根据纳入标准,在东山县选择孕妇140名、8~10岁儿童270名,在平潭县选择孕妇189名、8~10岁儿童368名。采集调查对象随机尿样、家中食用盐盐样测定碘含量,并对各人群进行碘营养评价;采用B型超声诊断仪进行甲状腺检查,同时进行甲状腺疾病问卷调查。分析不同区域8~10岁儿童及孕妇尿碘、盐碘、甲状腺结节间的相关关系。结果不同性别(男:151.30μg/L、女:130.30μg/L),区域(东山县:160.30μg/L、平潭县:129.70μg/L)儿童尿碘中位数比较差异均有统计学意义(P均<0.05);不同年龄(8、9、10岁:141.60、128.05、150.30μg/L)儿童尿碘中位数比较差异无统计学意义(P>0.05)。孕妇总体尿碘中位数为119.30μg/L,不同孕期、区域孕妇尿碘中位数比较差异均无统计学意义(P均>0.05)。儿童、孕妇盐碘中位数分别为20.30和23.65 mg/kg。儿童尿碘与盐碘呈正相关(r=0.13,P<0.05),孕妇尿碘与盐碘未见相关关系(P>0.05)。儿童甲状腺结节检出率为21.79%(139/638),不同年龄儿童甲状腺结节检出率比较差异有统计学意义(P<0.05);孕妇甲状腺结节检出率为4.26%(14/329)。儿童和孕妇甲状腺结节检出率与尿碘、盐碘均未见相关关系(P均>0.05)。两地儿童甲状腺容积均处于正常值范围内,甲状腺容积与尿碘、盐碘均未见相关关系(P均>0.05)。结论东山县和平潭县儿童碘营养均适宜(尿碘中位数100~199μg/L),孕妇均存在碘不足(尿碘中位数<150μg/L)。儿童尿碘与盐碘相关,尿碘随着盐碘的升高而升高。不同年龄儿童甲状腺结节患病情况不同,需要进一步研究求证。儿童和孕妇甲状腺结节检出率与尿碘、盐碘均不相关。Objective To understand the correlation between urinary iodine,salt iodine and thyroid nodules in children aged 8-10 years and pregnant women in different regions of Fujian Province,and to explore the influencing factors of thyroid diseases.Methods A cross-sectional study was conducted in Dongshan County and Pingtan County of Fujian Province from September to November 2019.According to the inclusion criteria,140 pregnant women and 270 children aged 8-10 years were selected in Dongshan County,and 189 pregnant women and 368 children aged 8-10 years were selected in Pingtan County.Random urine and edible salt samples were collected to determine iodine content,and iodine nutrition was evaluated in each population.Thyroid was examined by B ultrasound and questionnaire survey of thyroid diseases was carried out.The correlation between urinary iodine,salt iodine and thyroid nodules in children aged 8-10 years and pregnant women in different regions was analyzed.Results There were statistically significant differences in the median urinary iodine among children in different genders(male:151.30μg/L,female:130.30μg/L)and regions(Dongshan County:160.30μg/L,Pingtan County:129.70μg/L,P<0.05);there was no significant difference in the median urinary iodine among children of different ages(8,9,10 years old:141.60,128.05,150.30μg/L,P>0.05).The median urinary iodine among pregnant women was 119.30μg/L,and there was no significant difference in median urinary iodine among pregnant women in different stages and regions(P>0.05).The medians of salt iodine from children and pregnant women were 20.30 and 23.65 mg/kg,respectively.Urinary iodine in children was positively correlated with salt iodine(r=0.13,P<0.05).However,there was no correlation between urinary iodine and salt iodine in pregnant women(P>0.05).The detection rate of thyroid nodules in children was 21.79%(139/638).There was significant difference in the detection rate of thyroid nodules in children of different ages(P<0.05).The detection rate of thyroid nodules in pr

关 键 词：尿 碘 盐类 甲状腺结节 甲状腺容积 

分 类 号：R153[医药卫生—营养与食品卫生学]