布拉氏酵母菌散联合葡萄糖酸锌口服液、补液疗法治疗功能性消化不良患儿的效果观察  

Effects of saccharomyces boulardii sachets combined with zinc gluconate oral solution and rehydration therapy on functional dyspepsia in children

作　　者：袁巧云 刘文硕 李晓克 YUAN Qiaoyun;LIU Wenshuo;LI Xiaoke(Dept.of Pediatrics,Xiangcheng Hospital of Integrated Traditional Chinese and Western Medicine,Xiangcheng 461700;Henan Provincial People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]襄城中西医结合医院儿科,河南襄城461700 [2]河南省人民医院,河南郑州450000

出　　处：《华夏医学》2022年第2期91-96,共6页Acta Medicinae Sinica

摘　　要：目的:探讨布拉氏酵母菌散联合葡萄糖酸锌口服液、补液疗法治疗功能性消化不良(FD)患儿的效果。方法:选取FD患儿94例,按照治疗方案不同分为两组,每组各47例。对照组采用葡萄糖酸锌口服液与补液疗法治疗,联合组在对照组的基础上加用布拉氏酵母菌散治疗。比较两组临床疗效、治疗前后症状评分、炎症因子[血清干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)]水平、胃肠激素[胃动素(MTL)、生长抑素(SS)、胃泌素(GAS)]水平及不良反应发生情况。结果:治疗后,联合组症状评分(恶心呕吐、纳差少食、腹痛腹胀、泛酸嗳气)低于对照组(P<0.05);联合组总有效率97.87%高于对照组78.72%(P<0.05);联合组TNF-α、IFN-γ水平低于对照组(P<0.05);联合组MTL、GAS高于对照组,SS低于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:布拉氏酵母菌散联合葡萄糖酸锌口服液、补液疗法治疗FD患儿效果良好,可减轻患儿症状,缓解其体内炎症水平,改善患儿胃肠激素水平,且安全性较高。Objective:To investigate the effects of saccharomyces boulardii sachets combined with zinc gluconate oral solution and rehydration therapy on children with functional dyspepsia(FD).Methods:94 children with FD were divided into two groups according to different treatment regimens,with 47 cases in each group.The control group were given zinc gluconate oral solution and rehydration therapy,while the combined treatment group were treated with saccharomyces boulardii sachets on the basis of the treatment for the control group.Then,the clinical efficacy,symptom scores,levels of inflammatory factors[interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α)],gastrointestinal hormones[serum motilin(MTL),somatostatin(SS)and gastrin(GAS)]before and after treatment,and incidence of adverse reactions were compared between the two groups.Results:After treatment,symptom scores(such as nausea and vomiting,poor appetite,abdominal pain and distension,acid regurgitation and belching)in the combined treatment group were lower than those in the control group(P<0.05);the total effective rate in combined treatment group was 97.87%,higher than 78.72%in control group(P<0.05);TNF-αand IFN-γwere lower than those in control group(P<0.05);MTL and GAS were higher than those in the control group,while SS was lower than that in the control group(P<0.05);and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Saccharomyces boulardii sachets combined with zinc gluconate oral solution and rehydration therapy has a good effect on the treatment of FD in children,which can alleviate the symptoms,relieve the level of inflammation in the body and improve the level of gastrointestinal hormones in children.Besides,it is of highly safety.

关 键 词：功能性消化不良 布拉氏酵母菌散 葡萄糖酸锌口服液 补液疗法 

分 类 号：R573[医药卫生—消化系统]