生物活性玻璃对人工牙本质龋再矿化的影响  

Effects of bioactive glass on remineralization of artificial dentin caries

作　　者：岳阳丽[1] 刘翠丽 贺贵天 马贵霞 YUE Yangli;LIU Cuili;HE Guitian;MA Guixia(Department of Dentistry and Endodontics,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院牙体牙髓科,郑州450052

出　　处：《郑州大学学报（医学版）》2022年第3期392-395,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省科技厅科技攻关项目(162102310129)。

摘　　要：目的:评估BioMinF、奥敏清两种生物活性玻璃(BAG)促进人工牙本质龋再矿化的效果。方法:采用酸性脱矿液浸泡法制备40个人工牙本质龋样本,随机分为4组,每组10个,分别采用BioMinF(A组)、奥敏清(B组)、奥敏清+氟化钠(C组)和氟化钠(D组)进行再矿化处理。样本进行8 d的pH循环后,Micro-CT测定样本不同深度的矿物质密度(DMD)、矿物质获得量(ΔDMD)和病损深度的变化(ΔLD)。结果:在同一病损深度,各组b区的DMD均高于a区。A、B、C 3组b区牙本质病损表层的DMD接近于c区表层的DMD;D组b区牙本质病损表层的DMD则小于c区。4组ΔDMD值和ΔLD值比较,差异有统计学意义(P<0.05),C组大于A组和B组,D组小于A组和B组。4组ΔLD值比较,差异有统计学意义(P<0.05),C组大于B组,B组大于A组,A组大于D组(P<0.05)。结论:两种BAG均能促进牙本质再矿化,奥敏清和氟化钠联合使用效果最佳,BAG和氟化物在牙本质再矿化作用中具有协同作用。Aim:To evaluate the effects of BioMinF and Aominqing in promoting the remineralization of artificial dentin caries.Methods:Forty artificial dentin caries samples were prepared by acid demineralization solution immersion and randomly divided into 4 groups(n=10).BioMinF(group A),Aominqing(group B),Aominqing+NaF(group C),and NaF(group D) were used for remineralization.After pH cycling of samples for 8 days,Micro-CT was used to measure dentin mineral density(DMD) with different depth,the amount of mineral acquisition(ΔDMD) and the changes in the depth of the lesion(ΔLD).Results:DMD in zone b was higher than that in zone a at the same lesion depth.In group A,B and C,the DMD of dentin lesion surface in zone b was close to that in zone c,while in group D the DMD of dentin lesion surface in zone b was less than that in zone c.The differences of ΔDMD values of the 4 groups were statistically significant(P<0.05).The ΔDMD values of group C was larger than those of group A and B,and the ΔDMD value of group D was smaller than those of group A and B.The ΔLD values of the 4 groups were as follows:group C>group B>group A>group D(P<0.05).Conclusion:Two bioactive glasses can promote dentin remineralization,and the combination of Aominqing and NaF has the best effect;bioactive glasses and fluoride have a synergistic effect in dentin remineralization.

关 键 词：BioMinF 奥敏清 人工牙本质龋 再矿化 MICRO-CT 

分 类 号：R781.1[医药卫生—口腔医学]