血清CRP与肿瘤标志物检测在消化道恶性肿瘤诊断中的价值  

Value of serum CRP and tumor markers detection in diagnosing digestive tract malignant tumors

作　　者：陈阿红[1] 周小安[1] 花睿 CHEN Ahong;ZHOU Xiaoan;HUA Rui(Department of Clinical Laboratory,Taizhou Municipal Hospital of Traditional Chinese Medicine,Taizhou,Jiangsu 225300,China)

机构地区：[1]江苏省泰州市中医院检验科,江苏泰州225300

出　　处：《检验医学与临床》2022年第11期1502-1504,1509,共4页Laboratory Medicine and Clinic

摘　　要：目的分析血清C反应蛋白(CRP)与肿瘤标志物检测在消化道恶性肿瘤诊断中的价值。方法选择2017年6月至2021年6月该院接诊的消化道恶性肿瘤患者150例纳入恶性组、消化道良性病变患者150例纳入良性组,体检健康者150例纳入对照组,均行血清CRP、肿瘤标志物[糖类抗原125(CA125)、糖类抗原724(CA724)、糖类抗原199(CA199)、癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原50(CA50)]检测,评价良、恶性组治疗前后,对照组体检时,恶性组不同阶段测定结果。结果(1)入院时,恶性组、良性组的CRP、肿瘤标志物水平均高于对照组(P<0.05);恶性组肿瘤标志物水平均高于良性组(P<0.05)。(2)与治疗前比较,恶性组各疾病亚组患者在接受治疗后,其CRP阳性率、肿瘤标志物阳性率降低,差异有统计学意义(P<0.05)。(3)与治疗后比较,随访的51例复发患者其血清CRP、肿瘤标志物水平升高,差异有统计学意义(P<0.05)。结论血清CRP、肿瘤标志物在筛查消化道恶性肿瘤时有一定价值,血清CRP能够预警术后肿瘤复发。Objective To analyze the value of serum C-reactive protein(CRP)and tumor markers in the diagnosis of gastrointestinal malignant tumors.Methods One hundred and fifty patients with digestive tract malignant tumors in this hospital from June 2017 to June 2021 were selected as the malignant group,150 patients with digestive tract benign lesions were included in the benign group,and 150 healthy people undergoing physical examination were included in the control group.The serum CRP and tumor markers[carbohydrate antigen 125(CA125),carbohydrate antigen 724(CA724),carbohydrate antigen 199(CA199),carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),carbohydrate antigen 50(CA50)]were detected.The detection results before and after treatment in benign and malignant groups,at the physical examination in the control group and different stages in malignant group were evaluated.Results(1)At admission,the levels of CRP and tumor markers in the malignant group and benign group were higher than those in the control group(P<0.05);the levels of tumor markers in the malignant group were higher than those in the benign group(P<0.05);(2)compared with those before treatment,the positive rate of CRP and positive rates of tumor markers in the each disease subgroups of the malignant group were decreased after treatment,and the differences were statistically significant(P<0.05);(3)compared with those after treatment,the levels of serum CRP and tumor markers in 51 follow up patients with recurrence were increased,and the differences were statistically significant(P<0.05).Conclusion The detection of CRP and tumor markers have some value in screening digestive tract malignant tumors.Serum CRP could forewarn the recurrence of tumor.

关 键 词：糖类抗原 癌胚抗原 甲胎蛋白 C反应蛋白 大肠癌 胃癌 

分 类 号：R735[医药卫生—肿瘤] R446.1[医药卫生—临床医学]