颅内神经内分泌癌的诊治分析(附15例报道)  

Diagnosis and treatment of patients with intracranial neuroendocrine carcinoma(report of 15 cases)

作　　者：陆冬 王子德 王强 谢满意 LU Dong;WANG Zi-de;WANG Qiang;XIE Man-yi(Department of Neurosurgery,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属医院神经外科,江苏徐州221000

出　　处：《中国临床神经外科杂志》2022年第4期252-254,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨颅内神经内分泌癌的临床特征、治疗方法及预后。方法回顾性分析2013年9月至2018年9月手术治疗的15例颅内神经内分泌癌的临床资料。结果15例中,单发病灶3例。多发病灶12例。3例单发病灶术中显微镜下全切除,其余12例仅切除引起明显颅内压增高、短期威胁病人生命的病灶;术后病理显示小细胞神经内分泌癌9例,大细胞神经内分泌癌6例。术后仅行放疗8例,同时行放化疗4例,拒绝放化疗1例。术后随访1~12个月,死亡14例,平均生存时间为8个月;1例随访12个月生活基本自理。结论颅内神经内分泌癌是一类罕见的恶性脑肿瘤,预后差,临床症状和影像学表现缺乏特异性,诊断依靠术后病理学检查,治疗仍然以手术切除为主,辅以放、化疗的综合治疗。Objective To investigate the clinical features,treatment and prognosis of patients with intracranial neuroendocrine carcinoma.Methods The clinical data of 15 patients with intracranial neuroendocrine carcinoma who underwent microsurgery from September 2013 to September 2018 were retrospectively analyzed.Results Of these 15 patients,3 patients had only one lesion and 12 patients had multiple lesions.The lesions were totally resected under the microscope in 3 patients with one lesion,and only the lesions that causing obvious intracranial pressure increase of the other 12 patients with multiple lesions were totally resected.Postoperative pathological examination showed small cell neuroendocrine carcinoma in 9 patients and large cell neuroendocrine carcinoma in 6 patients.Eight patients received radiotherapy after the operation,4 received concurrent radiotherapy and chemotherapy,and 1 refused radiotherapy and chemotherapy.The follow-up(range,1~12 months)showed that 14 patients died with an average survival time of 8 months,and 1 patient survived for 12 months and he basically took care of himself.Conclusions Intracranial neuroendocrine carcinoma,lacking specificity in clinical symptoms and imaging manifestations,is a rare malignant brain tumor with poor prognosis.The definite diagnosis of intracranial neuroendocrine carcinoma depends on the postoperative pathological examination.The treatment is still based on surgical resection,supplemented by a combination of radiotherapy and chemotherapy.

关 键 词：颅内神经内分泌癌 临床特征 诊断 治疗 预后 

分 类 号：R739.41[医药卫生—肿瘤] R651.11[医药卫生—临床医学]