MicroRNA与白内障发病相关性的研究进展  

Research progress of correlation between microRNA and the pathogenesis of cataract

作　　者：蒲雅迪(综述) 李元彬(审校)[1] Pu Yadi;Li Yuanbin(Department of Ophthalmology,Yantai Yuhuangding Hospital Affiliated to Qingdao University,Yantai 264000,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院眼科,烟台264000

出　　处：《中华实验眼科杂志》2022年第5期475-480,共6页Chinese Journal Of Experimental Ophthalmology

摘　　要：微小RNA(miRNA)是一种非编码小分子RNA,可以特异性结合目标mRNA的3'非翻译区,从而诱导目标mRNA降解或抑制其翻译,最终影响细胞增生、分化以及凋亡等重要的生物学过程。白内障是全球首位致盲眼病,是一种由晶状体混浊引起的视力下降疾病,包括年龄相关性白内障、糖尿病性白内障、先天性白内障及后发性白内障。近年来研究发现,多种miRNA在晶状体组织中表达,影响晶状体上皮细胞的增生、迁移、上皮-间质转化及凋亡,参与不同类型白内障的发生及发展。本文就不同miRNA在各类型白内障中作用机制的研究进展进行综述,从而为白内障的防治提供新的思路与方法。MicroRNA(miRNA)is a kind of small non-coding RNA,which can specifically bind to the 3'untranslated region of the target RNA,inducing the degradation or inhibiting the translation of the target mRNA,and ultimately affecting the important biological processes such as cell proliferation,differentiation,and apoptosis.Cataract,a leading blinding eye disease in the world,is a kind of disease that causes blindness because of lens opacification,including age-related cataracts,diabetic cataracts,congenital cataracts and posterior capsule opacification.In recent years,it has been found that many kinds of miRNA are expressed in lens and participate in the development of cataract,having significant influences on the proliferation,migration,epithelial-mesenchymal transition and apoptosis of lens epithelial cells,and take part in the occurrence and development of cataracts.The advances of different miRNAs in cataract were reviewed in this article so as to provide new ideas and methods for the prevention and treatment of cataract.

关 键 词：非编码RNA 微小RNA 白内障 晶状体上皮细胞 

分 类 号：R776.1[医药卫生—眼科]