基于透明质酸超分子特性对中药小分子化合物功能改进的研究进展  

Research progress on improvement of functions of small molecular compounds of traditional Chinese medicine based on supramolecular properties of hyaluronic acid

作　　者：袁枝花 刘有停 曲召辉 邱显荣 王志家 皮雯敏 林晓钰 王鹏龙[1] YUAN Zhi-hua;LIU You-ting;QU Zhao-hui;QIU Xian-rong;WANG Zhi-jia;PI Wen-min;LIN Xiao-yu;WANG Peng-long(Department of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 102488,China;Taihe Kangmei Chinese Medicine Research Institute Co.,Ltd.,Beijing 102400,China;Zhiran Tiancheng Biotechnology Co.,Ltd.,Beijing 101299,China;Beijing Oriental Miaosen Biotechnology Co.,Ltd.,Beijing 101299,China)

机构地区：[1]北京中医药大学中药学院,北京102488 [2]太和康美中医研究院有限公司,北京102400 [3]植然天成生物科技有限公司,北京101299 [4]北京东方淼森生物科技有限公司,北京101299

出　　处：《药学学报》2022年第5期1245-1251,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82073974,81603256);北京市自然科学基金面上项目(7202116);北京市科技新星计划(Z201100006820026);中华中医药学会青年人才托举工程项目(CACM-2018-QNRC2-B08);北京中医药大学重点攻关项目(2020-JYB-ZDGG-044);北京中医药大学杰出青年人才基金(BUCM-2019-JCRC002)。

摘　　要：透明质酸由于其良好的生物相容性、可降解性、亲水性、肿瘤靶向性、黏性等特征广泛应用于生物材料、化妆品、临床医学等领域。中药小分子化合物具有显著的药效学活性,但仍存在溶解度低、靶向性差等缺点,这使其临床应用受到限制。基于透明质酸的超分子特性,本文汇总了国内外众多学者利用透明质酸作为载体对中药小分子化合物的溶解性、生物利用度、靶向性、适宜剂型等进行改善和功能提高的研究,将对挖掘中药小分子化合物潜在应用价值及新药研发提供新的思路和启发。Hyaluronic acid is widely used in biomaterials,cosmetics,clinical medicine and other fields due to its good biocompatibility,degradability,hydrophilicity,tumor targeting,viscosity and other characteristics.Pharmacodynamic activities of natural small molecular products which derived from traditional Chinese medicine(TCM)are significant,but their low solubility and poor targeting limit the clinical application.Based on supramolecular properties of hyaluronic acid,in this review,numerous studies were reviewed on the improvement of solubility,bioavailability,targeting and suitable dosage forms of small molecular compounds in TCM by domestic and foreign scholars using hyaluronic acid as carrier.It provides new ideas and inspirations for exploring the potential application value of small molecule compounds in TCM and even for the research and development of new drugs.

关 键 词：透明质酸 超分子化学 中药 小分子化合物 功能特性 

分 类 号：R965[医药卫生—药理学]