恩度、顺铂及重组人白介素-2联合热疗治疗恶性腹腔积液的临床观察  

Clinical observation of Endostar,cisplatin and recombinant human interleukin-2 combined with hyperthermia in the treatment of malignant peritoneal effusion

作　　者：张燕 霍忠超[2] ZHANG Yan;HUO Zhongchao(Medical College,Hebei University of Engineering,Handan,Hebei,056000,China;Oncology Department,the Affliated Hospital of Hebei University of Engineering,Handan,Hebei,056000,China)

机构地区：[1]河北工程大学临床医学院,河北邯郸056000 [2]河北工程大学附属医院肿瘤科,河北邯郸056000

出　　处：《肿瘤药学》2022年第2期228-233,共6页Anti-Tumor Pharmacy

基　　金：湖南佑立医疗科技有限公司科研项目(UNRLKYJJ-2018FFZY001)。

摘　　要：目的研究腹腔内注射恩度、顺铂、重组人白介素-2联合热疗治疗恶性肿瘤引起的恶性腹腔积液的临床疗效。方法选取2017年1月—2020年6月河北工程大学附属医院收治的60例恶性腹腔积液患者为研究对象,分为观察组和对照组,各30例。观察组腹腔注射恩度30 mg、顺铂60 mg、重组人白介素-2200万IU联合微波热疗,对照组腹腔注射顺铂60 mg、重组人白介素-2200万IU联合微波热疗,比较两组患者的临床疗效及副反应。结果观察组总有效率(90.0%)显著高于对照组(73.3%)(P=0.03),生活质量改善率(80%)显著高于对照组(60%)(P=0.043);两组患者出现的副反应主要为发热、恶心呕吐、食欲下降、乏力、血小板减少、贫血,发生率的差异无统计学意义(P=0.55)。结论腹腔内注射恩度、顺铂、重组人白介素-2联合热疗治疗恶性腹腔积液安全有效,可明显减轻患者痛苦,改善生活质量,副反应轻且可控制,值得临床推广应用。Objective To study the clinical efficacy of intraperitoneal injection of Endostar,cisplatin and recombinant human interleukin-2(rhIL-2)combined with hyperthermia in the treatment of malignant peritoneal effusion caused by ma‑lignant tumor.Methods A total of 60 patients with malignant abdominal effusion admitted to the Affiliated Hospital of He‑bei University of Engineering between January 2017 and June 2020 were selected.They were divided into observation group(n=30)and control group(n=30).The observation group received intraperitoneal injection of Endostar 30 mg+cispla‑tin 60 mg+rhIL-22×10^(6) IU and combined with microwave hyperthermia,while the control group received intraperitoneal injection of cisplatin 60 mg+rhIL-22×10^(6) IU and combined with microwave hyperthermia.The clinical efficacy and side effects of the two groups were analyzed.Results The total effective rate of the observation group(90.0%)was significantly higher than that of the control group(73.3%)(P=0.03).The improvement rate of the quality of life was also higher in the ob‑servation group(80%)than in the control group(60%)(P=0.043).The main adverse reactions in both groups included fever,nausea and vomiting,poor appetite,fatigue,thrombocytopenia and anemia,but no statistical differences were found in their incidence rates between the two groups(P=0.55).Conclusion Intraperitoneal injection of Endostar,cisplatin and rhIL-2 combined with hyperthermia is safe and effective in the treatment of malignant peritoneal effusion.This treatment method can significantly reduce the pain of patients and improve the quality of life.The side effects are mild and controllable.So it is worth clinical promotion.

关 键 词：恶性腹腔积液 恩度 顺铂 重组人白介素-2 热疗 

分 类 号：R730.6[医药卫生—肿瘤]