地西泮或阿普唑仑联合常规给药方案治疗功能性胃肠病伴焦虑患者的临床观察  

Clinical Observation of Diazepam/Alprazolam Combined with Conventional Drug Regimen in the Treatment of Functional Gastrointestinal Disorder with Anxiety Disorder

作　　者：张兰芳[1] 郭晓鹤[1] ZHANG Lan-fang;GUO Xiao-he(Department of Gastroenterology,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院消化内科,新乡453100

出　　处：《中国合理用药探索》2022年第4期44-48,共5页Chinese Journal of Rational Drug Use

基　　金：河南省医学科技攻关计划项目(LHGJ20210539)。

摘　　要：目的:考察地西泮或阿普唑仑联合常规药物治疗功能性胃肠病(FGID)伴焦虑患者的临床效果。方法:选取2018年1月~2021年9月期间本院消化内科收治的130例FGID伴焦虑患者进行临床观察。按随机数字表法分为对照组和观察组,每组65例。对照组给予常规药物治疗,观察组在对照组治疗基础上加服地西泮或阿普唑仑。对比两组的治疗有效率、药物相关不良反应发生率及汉密尔顿焦虑量表(HAMA)评分。结果:观察组腹痛、便秘症状的改善有效率高于对照组,且治疗总有效率高于对照组(P<0.05);两组药物相关不良反应发生率比较无统计学差异(P>0.05);治疗后,两组患者HAMA评分均降低,且观察组低于对照组(P<0.05)。结论:地西泮或阿普唑仑联合常规药物治疗方案对FGID伴焦虑患者的临床治疗效果更佳,可更好地缓解患者腹痛、便秘和焦虑症状,且安全性较高。Objective:To investigate the clinical effects of Diazepam/Alprazolam combined with conventional drugs in functional gastrointestinal disorder(FGID)patients with anxiety.Methods:From January 2018 to September 2021,a total of 130 FGID patients with anxiety admitted in the department of gastroenterology of our hospital were selected for clinical observation.All patients were randomly divided into the control group and the observation group according to the random number table method,65 cases in each group.The control group was given routine drug regimen,and the observation group was given routine drug combined with diazepam/alprazolam.The treatment efficiency,incidence of drug-related adverse reactions and Hamilton anxiety scale(HAMA)scores were compared between the two groups.Results:The effective rate of improving abdominal pain and constipation in the observation group was higher than that in the control group,and the total clinical effective rate was higher than that of the control group(P<0.05).There was no significant difference in the incidence of drug-related adverse reactions between the two groups(P>0.05).After treatment,HAMA scores in the two groups were decreased,and the observation group was lower than the control group(P<0.05).Conclusion:Diazepam/alprazolam combined with conventional drugs have a better clinical treatment effect on functional gastrointestinal disorder patients with anxiety,which can better alleviate the symptoms of abdominal pain,constipation and anxiety symptoms with high safety.

关 键 词：功能性胃肠病 苯二氮类药物 焦虑 临床效果 安全性 

分 类 号：R749.72[医药卫生—神经病学与精神病学]