Orexin receptor type 2 agonism inhibits thermogenesis in brown adipose tissue by attenuating afferent innervation  

作　　者：Mo-qiu Jia Yong-jin Wang Kang Fu Han Jiao Jia Sun Yuanqing Gao 

机构地区：[1]Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China

出　　处：《The Journal of Biomedical Research》2022年第3期195-207,I0005,I0006,共15页生物医学研究杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (Grants No. 31800971 and 81873654)

摘　　要：Orexin signaling has been associated with energy expenditure and brown adipose tissue(BAT)function.However,conflicting data exist in the field about how orexin signaling regulates BAT thermogenesis.In this study,we show that a specific orexin receptor type 2(OX2R)agonist[Ala11,D-Leu15]-OxB(OB-Ala)inhibited intrascapular brown adipose tissue(iBAT)thermogenesis by reducing sympathetic output to iBAT.This effect is mediated by OX2Rs located on afferent nerve endings innervating iBAT instead of brown adipocyte itself.Microinjection of OB-Ala into iBAT inhibited iBAT thermogenesis in mice upon cold exposure and neuronal activity in the paraventricular nucleus.Findings suggest that OB-Ala could inhibit iBAT thermogenesis by attenuating sensory input thereby inhibiting the sympathetic-sensory iBAT feedback loop.Our study uncovers a novel primary action site of orexin in the regulation of energy balance.

关 键 词：orexin receptor type 2 brown adipose tissue THERMOGENESIS 

分 类 号：R965[医药卫生—药理学]