THERMOGENESIS

作品数：51被引量：168H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：李仲李俊王欣佩袁梽漪雷帆更多>>
相关机构：南京医科大学江西中医药大学重庆医科大学复旦大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《流程工业》更多>>
相关基金：国家自然科学基金高等学校学科创新引智计划国家重点基础研究发展计划中国博士后科学基金更多>>
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Decreased basal thermogenesis is associated with the downregulation of cellular metabolic activity of organs and serum thyroid hormones in fasting Eurasian Tree Sparrows(Passer montanus)
《Avian Research》2025年第1期39-52,共14页Hong Jin Qi Xia Ziqing Gao Yujie XuanYuan Beibei Dong Ming Li Qingjian Liang Jinsong Liu 
financially supported by grants from the National Natural Science Foundation of China (Nos.32371573,32171497,and 31971420)。
Food is a critical environmental factor that influences animal survival,especially for small passerines due to their high mass-specific metabolic rates.Basal metabolic rate(BMR)reflects the energy expended by endother...
关键词：Basal metabolic rate Energy metabolism FASTING Passer montanus Thyroid hormones av-UCPmRNA 
Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome
《Acta Pharmaceutica Sinica B》2024年第12期5267-5285,共19页Shaocong Hou Hengcai Yu Caihong Liu Andrew M.F.Johnson Xingfeng Liu Qian Jiang Qijin Zhao Lijuan Kong Yanjun Wan Xiaowei Xing Yibing Chen Jingwen Chen Qing Wu Peng Zhang Changtao Jiang Bing Cui Pingping Li 
supported by grants from the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-016,2016-I2M-1-011,2016-I2M-3-008 and 2017-I2M-1-008,China);the Special Research Fund for Central Universities,Peking Union Medical College(3332022047,China);the Beijing Outstanding Young Scientist Program(BJJWZYJH01201910023028,China);the National Natural Science Foundation of China(81703588,82473984,81622010,81770800,and 81874316);the CAMS Central Public-interest Scientific Institution Basal Research Fund(2017RC31009 and 2018PT35004,China);the Drug Innovation Major Project from the National Science and Technology Department(2018ZX09711001-003-005 and 2018ZX09711001-003-001,China);the National Key R&D Program of China(2017YFA0205400 and 2022YFC2505204,China).
Nuclear receptor corepressor(NCoR1)interacts with various nuclear receptors and regulates the anabolism and catabolism of lipids.An imbalance in lipid/energy homeostasis is also an important factor in obesity and meta...
关键词：Nuclear receptor co-repressor 1 Intestinal epithelium Metabolic syndrome PPAR alpha Liver X receptor THERMOGENESIS SUCCINATE CHOLESTEROL 
Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator被引量：1
《Food Science and Human Wellness》2024年第5期2917-2936,共20页Peng Ma Jie Xiao Biyu Hou Ping He Xinyu Yang Yisa Wang Zijing Wang Tianshu Xu Xiuying Yang Xuan Zhu Shasha Xiang Song Li Guanhua Du Jian Ying Guifen Qiang 
funded by National Natural Science Foundation of China(NSFC 82070877);CAMS Innovation Fund for Medical Sciences(CIFMS)(2022-I2M-JB-010,2021-I2M-1-005);The National High Technology Research and Development Program of China(2017YFE0112900).
Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a“disease”.Brown adipose tissue(BAT)thermogenesis and white adipose tissue(WAT)browning emerge as a potential strateg...
关键词：OBESITY Black tea THERMOGENESIS BROWNING Adipose tissue 
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling
《Journal of Animal Science and Biotechnology》2024年第3期1008-1026,共19页Le Zhao Haili Yang Minhao Li Min Xiao Xingchun Li Lei Cheng Wenqiang Cheng Meixi Chen Yongju Zhao 
This work was financially supported by The National Key Research and Development Program of China(No.2022YFD1300202);The National Natural Science Foundation of China(No.32372834);Chongqing Modern Agricultural Industry Technology System(CQMAITS202313);the Collection,Utilization and Innovation of Germplasm Resources by Research Institutes and Enterprises of Chongqing,China(cqnyncw-kqlhtxm);the Chongqing Postgraduate Research Innovation Project(CYB22141).
Background Brown adipose tissue(BAT)is known to be capable of non-shivering thermogenesis under cold stimulation,which is related to the mortality of animals.In the previous study,we observed that goat BAT is mainly l...
关键词：Adipose remodeling Brown adipose tissue Goat kids Key thermogenesis-related genes WHITENING 
CMKLR1 senses chemerin/resolvin E1 to control adipose thermogenesis and modulate metabolic homeostasis
《Fundamental Research》2024年第3期575-588,共14页Zewei Zhao Siqi Liu Bingxiu Qian Lin Zhou Jianglin Shi Junxi Liu Lin Xu Zhonghan Yang 
funded by the National Natural Science Foundation of China(81570764);Guangzhou Science and Technology Project(201807010069);Shenzhen Science and Technology Project(JCYJ20190807154205627);Guangdong Natural Science Fund(2020A1515010365);Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translation Research of Hakka Population(2018B030322003KF01)received by Zhonghan Yang。
Induction of beige fat for thermogenesis is a potential therapy to improve homeostasis against obesity.β3-adrenoceptor(β3-AR),a type of G protein-coupled receptor(GPCR),is believed to mediate the thermogenesis of br...
关键词：Obesity Insulin resistance THERMOGENESIS CMKLR1 Resolvin E1 CHEMERIN 
Mitochondrial flashes are interlinked with adaptive thermogenesis in brown adipocytes被引量：1
《hLife》2024年第4期179-188,共10页Xinyu Chen Huwatibieke Bahetiyaer Xuejiao Song Zuzhi Jiang Wenfeng Qi Weizheng Gao Lin Zhang Jue Zhang Heping Cheng Xianhua Wang 
supported by the National Natural Science Foundation of China(31971158,92157105,and 32293210);the National Science and Technology Innovation 2030Major Program(2022ZD0211900);CAMS Innovation Fund for Medical Sciences(2019-I2M-5–054).
Mitochondrial flash(mitoflash)is the electrochemical excitation of a single mitochondrion and plays diverse signaling roles in a variety of cells.From the viewpoint of bioenergetics,it represents the transient uncoupl...
关键词：mitochondrial flash(mitoflash) MITOCHONDRIA THERMOGENESIS brown adipocyte 
Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5‑HT pathway
《Journal of Animal Science and Biotechnology》2024年第2期679-698,共20页Sheng Li Xiaoqing Li Kai Wang Yansen Li Kentaro Nagaoka Chunmei Li 
the National Natural Science Foundation of China,grant numbers 32372935,32072781.
Background Broilers have a robust metabolism and high body temperature,which make them less tolerant to hightemperature(HT)environments and more susceptible to challenges from elevated temperatures.Gut microbes,functi...
关键词：5-HT Broiler chickens Gut microbiota THERMOGENESIS THERMOREGULATION 
Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition
《Acta Pharmaceutica Sinica B》2024年第4期1711-1725,共15页Yingting Wu Jiaqi Xin Xinyu Li Ting Yang Yi Liu Yongsheng Zhao Wen Xie Mengxi Jiang 
This work was supported by the Beijing Municipal Natural Science Foundation Grant 7212148(to Mengxi Jiang,China);the National Natural Science Foundation of China Grant 82000807(to Mengxi Jiang,China);the Beijing Municipal Education Commission Grant KM202110025023(to Mengxi Jiang,China).
Drug repurposing offers an efficient approach to therapeutic development.In this study,our bioinformatic analysis first predicted an association between obesity and lansoprazole(LPZ),a commonly prescribed drug for gas...
关键词：LANSOPRAZOLE Proton pump inhibitors Adipose thermogenesis Energy expenditure Metabolic syndrome PHOSPHO1 inhibitor Cannabinoid receptor signaling Drug repurposing 
Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast
《Acta Pharmaceutica Sinica B》2024年第3期1472-1476,共5页Lina Tang Jianping Ye 
supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye。
Beige/brown adipocytes play a crucial role in regulating the body’s overall energy balance.The thermogenic function is under the influence of various tissues,including the brain,muscles,and liver.However,the breast t...
关键词：BEIGE BREAST Epitheliail cells scRNA-seq THERMOGENESIS 
A temperature-regulated bioorthogonal reaction to target lysine:Hemiacetal pharmacophore in genipin irreversibly binds with UCP2,inhibiting mitochondrial thermogenesis
《Chinese Chemical Letters》2023年第10期191-196,共6页Fukui Shen Wen Yang Kaixue Zhang Yanting Jiao Jing Cui Yuanyuan Hou Gang Bai 
supported by the National Natural Science Foundation of China(No.81973449);the National Key Research and Development Program of China(Nos.2018YFC1704800 and 2018YFC1704805);。
Mitochondria are essential for eukaryotic life as powerhouses for energy metabolism. Excessive mitochondrial hyperthermia and reactive oxygen species(ROS) production have been associated with aging, cancer,neurodegene...
关键词：Bioorthogonal reaction Mitochondria GENIPIN UCP2 Irreversible binding 
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