LANSOPRAZOLE

作品数：38被引量：204H指数：9
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相关领域：医药卫生更多>>
相关作者：王杨曹双叶利民李章万洪诤更多>>
相关机构：中国协和医科大学日本筑波大学广东省药物研究所华西医科大学更多>>
相关期刊：《Chinese Medical Journal》《World Journal of Gastrointestinal Endoscopy》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金更多>>
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Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition
《Acta Pharmaceutica Sinica B》2024年第4期1711-1725,共15页Yingting Wu Jiaqi Xin Xinyu Li Ting Yang Yi Liu Yongsheng Zhao Wen Xie Mengxi Jiang 
This work was supported by the Beijing Municipal Natural Science Foundation Grant 7212148(to Mengxi Jiang,China);the National Natural Science Foundation of China Grant 82000807(to Mengxi Jiang,China);the Beijing Municipal Education Commission Grant KM202110025023(to Mengxi Jiang,China).
Drug repurposing offers an efficient approach to therapeutic development.In this study,our bioinformatic analysis first predicted an association between obesity and lansoprazole(LPZ),a commonly prescribed drug for gas...
关键词：LANSOPRAZOLE Proton pump inhibitors Adipose thermogenesis Energy expenditure Metabolic syndrome PHOSPHO1 inhibitor Cannabinoid receptor signaling Drug repurposing 
Vonoprazan 10 mg or 20 mg vs.lansoprazole 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial
《Chinese Medical Journal》2024年第8期962-971,共10页Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen 
Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the esophagus.Proton pump inhibitors are widely used as maintenance therapy for EE,but many patients still rela...
关键词：Erosive esophagitis LANSOPRAZOLE Maintenance therapy Potassium-competitive acid blockers Vonoprazan 
Analysis and monitoring of drug therapy in a patient with peptic ulcer complicated by infection:A case report
《World Journal of Clinical Cases》2024年第8期1530-1535,共6页Yan-Ping Gou Yue Huang Li Chen Wei Zheng Yun-Hua Zheng 
BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese...
关键词：Ampicillin-sulbactam FAMOTIDINE LANSOPRAZOLE Kangfuxin Liquid Chinese pharmacist Case report 
The role of CYP1A1/2 in cholesterol ester accumulation provides a new perspective for the treatment of hypercholesterolemia被引量：2
《Acta Pharmaceutica Sinica B》2023年第2期648-661,共14页Jian Lu Xuyang Shang Bingyi Yao Dongyi Sun Jie Liu Yuanjin Zhang He Wang Jingru Shi Huaqing Chen Tieliu Shi Mingyao Liu Xin Wang 
supported in whole or part by grants from the National Natural Science Foundation of China(81773808,82274010);the Science and Technology Commission of Shanghai Municipality(18430760400,China);the Jointed PI Program from Shanghai Changning Maternity and Infant Health Hospital(2019CNECNUPI02,China);the Fundamental Research Funds for the Central Universities(China);ECNU Construction Fund of Innovation and Entrepreneurship Laboratory(China);supported from ECNU Multifunctional Platform for Innovation(011,China);the Instruments Sharing Platform of School of Life Sciences,East China Normal University(Shanghai,China)。
Cholesterol is an important precursor of many endogenous molecules.Disruption of cholesterol homeostasis can cause many pathological changes,leading to liver and cardiovascular diseases.CYP1A is widely involved in cho...
关键词：HYPERLIPIDEMIA HYPERCHOLESTEREMIA Cholesterol CYP1A LIPIDOSIS LXR CES1 LANSOPRAZOLE 
Release Profile of Lansoprazole Encapsulated in Sodium Alginate Beads
《Journal of Pharmacy and Pharmacology》2021年第5期197-204,共8页Jair Pereira de Melo Junior Vicente Guerra Filho Márcio Rosa JeováDavid Vinicius Cozadi de Souza Vergílio Pereira Carvalho 
Symptomatic gastroesophageal reflux disease (GERD) affects 11% of the population worldwide. Lansoprazole was the second commercially available proton pump inhibitor, recommended for healing and symptomatic relief of r...
关键词：SPECTROPHOTOMETRY proton pump inhibitor ENCAPSULATION sodium alginate beads. 
Simultaneous Determination of Amoxicillin, Lansoprazole, and Levofloxacin in Pharmaceuticals by HPLC with UV-Vis Detector被引量：2
《Journal of Analysis and Testing》2020年第1期45-53,共9页Mustafa Gülfen YazgiCanbaz AbdilÖzdemir 
In this study,a specific and rapid high-performance liquid chromatography(HPLC)method has been developed and validated for the simultaneous determination of amoxicillin,lansoprazole,and levofloxacin in pharmaceuticals...
关键词：HPLC AMOXICILLIN LEVOFLOXACIN LANSOPRAZOLE Simultaneous determination 
Preparation and stability study of lansoprazole for injection
《Journal of Chinese Pharmaceutical Sciences》2018年第6期442-450,共9页Zhenyu Lu Rong Xu Wei Dai Jing Lin Chen Shen 
In the present study, we aimed to assess the preparation method of sterile lansoprazole powder for injection, as well as its quality and stability. By cryodesiccation technology in combination with the control of its ...
关键词：LANSOPRAZOLE FREEZE-DRYING Preparation route Stability study 
Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole被引量：25
《World Journal of Gastroenterology》2018年第14期1550-1561,共12页Kiyoshi Ashida Katsuhiko Iwakiri Naoki Hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki 
funded by Takeda Pharmaceutical Company Limited
AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following...
关键词：GASTROESOPHAGEAL REFLUX disease EROSIVE ESOPHAGITIS LANSOPRAZOLE Potassium-competitive acid BLOCKERS Vonoprazan Maintenance therapy 
Identification of Oxidative Degradation Products of Lansoprazole by Using High Resolution Mass Spectrometry Spectral Data被引量：3
《International Journal of Analytical Mass Spectrometry and Chromatography》2017年第3期57-69,共13页Dev Kant Shandilya Rekha Israni Peter Edward Joseph Anoop Kumar Manoj Pillai 
The study focused on the application of high-resolution mass spectrometry for the identification of impurities in pharmaceutical small molecules. A high-performance liquid chromatography (HPLC) coupled high resolution...
关键词：LANSOPRAZOLE OXIDATIVE DEGRADATION PRODUCTS of LANSOPRAZOLE 
Formulation Optimization Utilizing D-Optimal Experimental Design of Oral Capsules Containing Enteric-Coated Pellets of Lansoprazole and<i>in vivo </i>Bioequivalence
《Pharmacology & Pharmacy》2017年第5期153-171,共19页Anh Quang Luong Thang Ngoc Vu Dang Hoa Nguyen Sultan M. Alshahrani John Mark Christensen Chien Ngoc Nguyen 
An optimized formulation of capsules containing Lansoprazole enteric-coated pellets using D-Optimal design with a polynomial statistical model were prepared by using Eudragit?L100 as an enteric coated polymer to provi...
关键词：LANSOPRAZOLE D-Optimal Pellets Enteric-Coating PHARMACOKINETIC Parameters 
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