BEIGE

作品数:32被引量:108H指数:5
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Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast
《Acta Pharmaceutica Sinica B》2024年第3期1472-1476,共5页Lina Tang Jianping Ye 
supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye。
Beige/brown adipocytes play a crucial role in regulating the body’s overall energy balance.The thermogenic function is under the influence of various tissues,including the brain,muscles,and liver.However,the breast t...
关键词:BEIGE BREAST Epitheliail cells scRNA-seq THERMOGENESIS 
Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment
《Journal of Molecular Cell Biology》2022年第12期46-62,共17页Xuekai Xiong Weini Li Ruya Liu Pradip Saha Vijay Yechoor Ke Ma 
supported by grants from National Institutes of Health(1R01DK112794);American Heart Association(17GRNT33370012);K.M.and from National Institutes of Health(DK097160-01 and 1R01DK130499)to V.Y。
The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor(MRTF)/serum response factor(SRF)activity...
关键词:circadian rhythm actin cytoskeleton adipocyte differentiation THERMOGENESIS energy balance glucose metabolism insulin sensitivity 
Lysyl oxidase inhibition enhances browning of white adipose tissue and adaptive thermogenesis被引量:1
《Genes & Diseases》2022年第1期140-150,共11页Chun Xing Duo Jiang Yang Liu Qiqun Tang Haiyan Huang 
This research was supported by National Natural Science Foundation(No.81770844,82070870 and 81170781 to H.Y.Huang).
Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure,ultimately reducing adiposity.Here,we report the central role of adipocyte-derived l...
关键词:Adaptive thermogenesis BAT Beige fat Lysyl oxidase TNFA 
Peptidoglycan inhibits beigeing of adipose tissue被引量:1
《Acta Pharmaceutica Sinica B》2022年第2期990-993,共4页Hong Chen Lijun Sun Lu Feng Michael Mulholland Weizhen Zhang Yue Yin 
supported by grants from the National Natural Science Foundation of China(81730020,81930015,and 82070592);National Institutes of Health Grant R01D K112755,1R01DK129360 and 1R01DK110273(USA)。
To the Editor:Obesity, an epidemic metabolic disease characterized by excessive fat accumulation, causes a significant economic burden on families and the society. The discovery of beige adipocytes has provided us wit...
关键词:Beige adipocytes Brown adipocytes OBESITY Metabolic inflammation 
Formation of thermogenic adipocytes: What we have learned from pigs被引量:1
《Fundamental Research》2021年第4期495-502,共8页Jianguo Zhao Cong Tao Chuanhe Chen Yanfang Wang Tianxia Liu 
This work was supported by the National Natural Science Foundation of China(31601008,81671274,31272440 and 31801031);the National Transgenic Project of China(2016ZX08009003–006–007)。
Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise. This distinct feature makes them...
关键词:THERMOGENESIS Beige adipocytes PIGS 
Potential protein–phenotype correlation in three lipopolysaccharideresponsive beige-like anchor protein-deficient patients
《World Journal of Clinical Cases》2021年第21期5873-5888,共16页Wen-Juan Tang Wen-Hui Hu Ying Huang Bing-Bing Wu Xiao-Min Peng Xiao-Wen Zhai Xiao-Wen Qian Zi-Qing Ye Hai-Jiao Xia Jie Wu Jie-Ru Shi 
BACKGROUND Patients with lipopolysaccharide(LPS)-responsive beige-like anchor protein(LRBA)deficiency have a variety of clinical symptoms,but there is no apparent genotype–phenotype correlation,and patients carrying ...
关键词:LPS-responsive beige-like anchor protein deficiency Chinese Common variable immunodeficiency Gene mutation Chronic diarrhea 
Beige adipocytes partly improved glucose intolerance of BAT-denervated mice
《解剖学杂志》2021年第S01期166-167,共2页Jia Xiaowei Lu Tao Yang Chun Gao Yan 
Beige adipocytes are emerging as an interesting issue in obesity and metabolism research.An important question is whether beige adipocytes have same functions as brown adipocytes.Therefore we did surgical denervation(...
关键词:METABOLISM ADIPOCYTE BAT 
In Situ Saturating Mutagenesis Screening Identifies a Functional Genomic Locus that Regulates Ucp1 Expression被引量:1
《Phenomics》2021年第1期15-21,共7页Yan Qiu Xiaojian Liu Yingmin Sun Shuang Li Yuda Wei Cheng Tian Qiurong Ding 
supported by grants from the National Key R&D Program of China(2017YFA0102800,2017YFA0103700);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030402);the National Natural Science Foundation of China(31670829,31971063).
A better understanding of the molecular mechanisms that control the UCP1 expression in brown and beige adipocytes is essential for us to modulate adipose cell fate and promote thermogenesis,which may provide a therape...
关键词:In situ saturating mutagenesis screen Brown and beige adipocytes UCP1 sgRNA-9768 
雷公藤红素对人急性早幼粒细胞白血病SCID小鼠移植瘤模型凝血功能的影响被引量:4
《中国中医急症》2019年第2期232-235,共4页王黎 秦桂芳 柯鸿 魏广民 
湖北省十堰市科技局科学研究资助项目(2017Y36)
目的观察雷公藤红素对人急性早幼粒细胞白血病重度联合免疫缺陷(SCID)小鼠移植瘤模型凝血功能的影响。方法 SCID beige小鼠30只,将其中20只采用尾静脉注射对数生长期的NB4细胞5×106个/只的方法建立人急性早幼粒细胞白血病SCID小鼠移植...
关键词:SCID beige小鼠 人急性早幼粒细胞白血病 雷公藤红素 凝血功能 生存时间 
Small molecules for fat combustion: targeting obesity被引量:24
《Acta Pharmaceutica Sinica B》2019年第2期220-236,共17页Jingxin Liu Yitao Wang Ligen Lin 
Financial support by Science and Technology Development Fund,Macao SAR,China(FDCT 102/2017/A);the Research Fund of University of Macao,China(MYRG2017-00109-ICMS)
Obesity is increasing in an alarming rate worldwide, which causes higher risks of some diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic approaches,either pancreatic lipase in...
关键词:THERMOGENESIS BROWN ADIPOSE tissue BEIGE cells OBESITY UNCOUPLING protein 1 
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