supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye。
Beige/brown adipocytes play a crucial role in regulating the body’s overall energy balance.The thermogenic function is under the influence of various tissues,including the brain,muscles,and liver.However,the breast t...
supported by grants from National Institutes of Health(1R01DK112794);American Heart Association(17GRNT33370012);K.M.and from National Institutes of Health(DK097160-01 and 1R01DK130499)to V.Y。
The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor(MRTF)/serum response factor(SRF)activity...
This research was supported by National Natural Science Foundation(No.81770844,82070870 and 81170781 to H.Y.Huang).
Accumulating evidence from both animal and human studies suggests that activation of beige fat increases cellular energy expenditure,ultimately reducing adiposity.Here,we report the central role of adipocyte-derived l...
supported by grants from the National Natural Science Foundation of China(81730020,81930015,and 82070592);National Institutes of Health Grant R01D K112755,1R01DK129360 and 1R01DK110273(USA)。
To the Editor:Obesity, an epidemic metabolic disease characterized by excessive fat accumulation, causes a significant economic burden on families and the society. The discovery of beige adipocytes has provided us wit...
This work was supported by the National Natural Science Foundation of China(31601008,81671274,31272440 and 31801031);the National Transgenic Project of China(2016ZX08009003–006–007)。
Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise. This distinct feature makes them...
BACKGROUND Patients with lipopolysaccharide(LPS)-responsive beige-like anchor protein(LRBA)deficiency have a variety of clinical symptoms,but there is no apparent genotype–phenotype correlation,and patients carrying ...
Beige adipocytes are emerging as an interesting issue in obesity and metabolism research.An important question is whether beige adipocytes have same functions as brown adipocytes.Therefore we did surgical denervation(...
supported by grants from the National Key R&D Program of China(2017YFA0102800,2017YFA0103700);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030402);the National Natural Science Foundation of China(31670829,31971063).
A better understanding of the molecular mechanisms that control the UCP1 expression in brown and beige adipocytes is essential for us to modulate adipose cell fate and promote thermogenesis,which may provide a therape...
Financial support by Science and Technology Development Fund,Macao SAR,China(FDCT 102/2017/A);the Research Fund of University of Macao,China(MYRG2017-00109-ICMS)
Obesity is increasing in an alarming rate worldwide, which causes higher risks of some diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic approaches,either pancreatic lipase in...