肌苷片联合托吡酯在儿童短暂性抽动障碍中的应用效果  

Application effect of Inosine Tablets combined with Topiramate in children with transient tic disorder

作　　者：吕冰聪[1] LYU Bingcong(Department of Pediatrics,Jiangmen Central Hospital,Guangdong Province,Jiangmen529000,China)

机构地区：[1]广东省江门市中心医院儿内科,广东江门529000

出　　处：《中国当代医药》2022年第12期92-95,共4页China Modern Medicine

基　　金：广东省江门市科技计划项目(2020020301420003445)。

摘　　要：目的探讨肌苷片联合托吡酯在儿童短暂性抽动障碍(TTD)中的应用效果。方法选取2019年2月至2021年2月广东省江门市中心医院门诊收治的86例TTD患儿的临床资料进行回顾性分析,按治疗方法的不同将其分为对照组(43例)和观察组(43例)。对照组患儿采用肌苷片治疗,观察组患儿加用托吡酯治疗,两组均持续用药24周。比较两组患儿的临床疗效、耶鲁综合抽动严重程度量表(YGTSS)评分、注意力缺陷多动障碍量表(ADHD)评分、每日抽动次数及不良反应发生情况。结果观察组患儿的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患儿治疗前的YGTSS评分比较,差异无统计学意义(P>0.05);两组患儿治疗后的YGTSS各项评分及总分低于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后的YGTSS各项评分及总分均低于对照组,差异有统计学意义(P<0.05);两组患儿治疗前的ADHD评分比较,差异无统计学意义(P>0.05);两组患儿治疗后的注意力缺陷、多动冲动评分及ADHD总分低于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后的注意力缺陷、多动冲动评分及ADHD总分均低于对照组,差异有统计学意义(P<0.05);两组患儿治疗前的每日抽动次数比较,差异无统计学意义(P>0.05);两组患儿治疗后的每日抽动次数少于治疗前,差异有统计学意义(P<0.05);观察组患儿治疗后的每日抽动次数少于对照组,差异有统计学意义(P<0.05);两组患儿的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论肌苷片联合托吡酯可提高儿童TTD的治疗效果,降低YGTSS评分及ADHD评分,减少每日抽动次数,安全可靠,值得广泛应用。Objective To investigate the application effect of Inosine Tablets combined with Topiramate in children with transient tic disorder(TTD).Methods The clinical data of 86 children with TTD admitted to the Outpatient Department of Jiangmen Central Hospital of Guangdong Province from February 2019 to February 2021 were retrospectively analyzed.They were divided into a control group(43 cases)and an observation group(43 cases)according to different treatment methods.The children in the control group were treated with Inosine Tablets,and the children in the observation group were additionally treated with Topiramate.Both groups were treated for 24 weeks.The clinical efficacy,Yale global tie severityb scale(YGTSS)score,attention deficit hyperactivity disorde(ADHD)score,daily tic times and adverse reactions were compared between the two groups.Results The total effectiveness rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the YGTSS score between the two groups before treatment(P>0.05).The items and total YGTSS scores of the observation group were lower than those before treatment,and the differences were statistically significant(P<0.05).The items and total YGTSS scores in the observation group after treatment were lower than those in the control group,with statistical significances(P<0.05).There were no significant differences in ADHD scores between the two groups before treatment(P>0.05).After treatment,the scores of attention deficit,hyperactivity and impulsivity and total ADHD scores of the two groups were lower than those before treatment,the differences were statistically significant(P<0.05).The attention deficit,hyperactivity and impulsivity scores and total ADHD score of the observation group were lower than those of the control group after treatment,the differences were statistically significant(P<0.05).There was no significant difference in the number of daily tic before treatment

关 键 词：儿童短暂性抽动障碍 肌苷片 托吡酯 安全性 

分 类 号：R749[医药卫生—神经病学与精神病学]