MnBr_(2)catalyzed regiospecific oxidative Mizoroki-Heck type reaction  

作　　者：Xiang Chen Zhihong Zhu Shanshan Liu Yi-Hung Chen Xiao Shen 

机构地区：[1]Institute for Advanced Studies,Engineering Research Center of Organosilicon Compounds&Materials,Ministry of Education,Wuhan University,Wuhan 430072,China

出　　处：《Chinese Chemical Letters》2022年第5期2391-2396,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (No. 21901191);the Fundamental Research Funds for the Central Universities and Wuhan University for financial support

摘　　要：Herein, we report an unprecedented regiospecific oxidative Mizoroki-Heck type reaction for the synthesis of α-difluoromethyl homoallylic alcohols. The reaction shows broad substrate scopes and high functional group tolerance. Late-stage functionalization of complex biologically active molecules demonstrates the synthetic potential of this transformation. Mechanistic study supports the involvement of MnBr_(2) catalyzed radical 1,2-silyl transfer.

关 键 词：FLUOROALKYLATION Mizoroki-Heck Mn catalysis Radical 1 2-silyl transfer Homoallylic alcohols 

分 类 号：TQ223.142[化学工程—有机化工] TQ426