Nanomaterials for neurodegenerative diseases:Molecular mechanisms guided design and applications  

作　　者：Tianzhong Li Xueyan Hou Yu Qi Xiaohan Duan Pengcheng Yan Haoru Zhu Zhongjian Xie Han Zhang 

机构地区：[1]Shenzhen International Institute for Biomedical Research,Shenzhen 518110,China [2]International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education,Institute of Microscale Optoelectronics,Shenzhen University,Shenzhen 518060,China [3]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China [4]Institute of Pediatrics,Shenzhen Children’s Hospital,Shenzhen 518038,China

出　　处：《Nano Research》2022年第4期3299-3322,共24页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Fund of China(No.61961136001);the Guangdong Basic and Applied Research Foundation(No.2019B1515120043);Natural Science Foundation of Guangdong Province(No.2020A151501612);the Science and Technology Project of Shenzhen(No.JCYJ20180508152903208);The authors also acknowledged the support from the Photonics Center and Instrumental Analysis Center of Shenzhen University.

摘　　要：Successful treatment of neurodegenerative diseases(NDDs),including Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD),remains a significant challenge for neurologists due to the undesirable curative outcomes.Apart from surgeries,most drugs are only used to relieve the patients’symptoms without a permanent cure of the disease.The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms.Considering the difficulties in NDD drug development and clinical trials,a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed.In the current article,the basic concepts and pathogenic characteristics of NDDs are firstly illustrated.Following the detailed description of molecular mechanisms underlying three common NDDs,recent advances of drug development based on targeting different pathogenic mechanisms are clarified.Hopefully,this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine.

关 键 词：neurodegenerative diseases molecular mechanisms NANOMATERIALS signaling pathways protein aggregation 

分 类 号：R74[医药卫生—神经病学与精神病学] R91[医药卫生—临床医学]