双歧杆菌三联活菌胶囊对代谢相关脂肪性肝病患者肠道菌群的影响  

Effect of Bifidobacterium Triple Viable Capsule on Intestinal Flora in Patients with Metabolic-Associated Fatty Liver Disease

作　　者：覃屹 谢榕[1] 唐少波[1] Qin Yi;Xie Rong;Tang Shao-bo(Department of Gastroenterology,Nanning First People's Hospital,Nanning 530022,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]南宁市第一人民医院消化内科,广西南宁530022

出　　处：《中国社区医师》2022年第14期52-54,共3页Chinese Community Doctors

摘　　要：目的:探讨双歧杆菌三联活菌胶囊对代谢相关脂肪性肝病(MAFLD)患者肠道菌群的影响。方法:收集南宁市第一人民医院2018年1月-2020年12月治疗的72例MAFLD患者,随机分成观察组和对照组各36例;对照组口服复方甘草酸苷片,2片/次,3次/d;观察组在对照组的基础上口服双歧杆菌三联活菌胶囊,420 mg/次,3次/d。两组患者均连续治疗30 d,在治疗期间禁止食用酸奶,不使用降血脂、降血糖及其他保肝药物,禁止使用其他抗生素、微生态制剂。结果:两组患者治疗前梭菌属、拟杆菌属、长双歧杆菌、粪球菌属、嗜酸乳杆菌属比较,差异无统计学意义(P>0.05);治疗后观察组梭菌属明显下降,拟杆菌属、长双歧杆菌、粪球菌属、嗜酸乳杆菌属明显高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前肝功能指标比较,差异无统计学意义(P>0.05);治疗后观察组谷丙转氨酶、谷草转氨酶均明显下降,观察组明显低于对照组,差异有统计学意义(P<0.05)。肝功能复常率观察组明显高于对照组,差异有统计学意义(P<0.05)。结论:双歧杆菌三联活菌胶囊能够调节MAFLD患者肠道菌群失调状况,改善肝功能,提高临床疗效,值得临床推广。Objective: To investigate the effects of bifidobacterium triple viable capsule on intestinal flora of patients with metabolism-related fatty liver disease(MAFLD). Methods: A total of 72 patients with MAFLD treated in Nanning First People’s Hospital from January 2018 to December 2020 were collected and randomly divided into observation group and control group,with 36 cases in each group. The control group was orally given compound glycyrrhizin tablets, 2 tablets per time, 3 times a day,and the observation group was orally given bifidobacteria triple viable capsule, 420 mg per time, 3 times a day on the basis of the control group. Patients in both groups were continuously treated for 30 days. During the treatment, yogurt was forbidden, lipidlowering, hypoglycemic and other liver-protecting drugs were not used, and other antibiotics and probiotics were prohibited.Results: Before treatment, there was no significant difference in Clostridium, Bacteroides, Bifidobacterium longum,Faecalibacterium and Lactobacillus acidophilus between the two groups(P>0.05);after treatment, Clostridium in the observation group decreased significantly, Bacteroides, Bifidobacterium longum, Faecalis, and Lactobacillus acidophilus were significantly higher than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in liver function indexes between the two groups before treatment(P>0.05);after treatment, all indexes of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the observation group were significantly decreased and significantly lower than those in the control group. The difference was statistically significant(P<0.05). The recovery rate of liver function in the observation group was significantly higher than that in the control group, and the difference was statistically significant(P<0.05).Conclusion: Bifidobacterium triple viable capsules can regulate the imbalance of intestinal flora in patients with MAFLD, improve liver function, and improve c

关 键 词：双歧杆菌三联活菌胶囊 代谢相关脂肪性肝病 肠道菌群 

分 类 号：R575.5[医药卫生—消化系统]