小儿脑性瘫痪合并癫痫的危险因素分析  

Risk Factors of Cerebral Palsy Complicated with Epilepsy in Children

作　　者：田小琴[1] 齐晓萌 麦玉真 叶敬花[1] Tian Xiao-qin;Qi Xiao-meng;Mai Yu-zhen;Ye Jing-hua(Department of Neurology,Shenzhen Children's Hospital of Guangdong Province,Shenzhen 518001,Guangdong;Province,China Outpatient Office,Shenzhen Children's Hospital of Guangdong Province,Shenzhen 518001,Guangdong Province,China)

机构地区：[1]广东省深圳市儿童医院神经内科,广东深圳518001 [2]广东省深圳市儿童医院门诊,广东深圳518001

出　　处：《中国社区医师》2022年第14期67-69,共3页Chinese Community Doctors

摘　　要：目的:探讨小儿脑性瘫痪合并癫痫的危险因素。方法:回顾性分析2018年7月-2020年7月在深圳市儿童医院接受治疗的80例小儿脑性瘫痪患者的临床资料,根据是否合并癫痫将其分为两组,分别为合并癫痫的癫痫组(n=28)与无癫痫发生的无癫痫组(n=52),对两组患儿的资料进行比较,并进行单因素分析与Logistic回归分析。结果:80例小儿脑性瘫痪患儿中28例合并癫痫,发生率为35.00%;癫痫组低出生体重、脑软化、颅内出血、脑结构畸形发生率较无癫痫组相比明显更高,差异有统计学意义(P<0.05);Logistic多因素分析结果显示,低出生体重(OR=2.785)、脑软化(OR=3.181)、颅内出血(OR=3.474)、脑结构畸形(OR=5.615)是小儿脑性瘫痪合并癫痫的独立危险因素(P<0.05)。结论:小儿脑性瘫痪患者中低出生体重、脑软化、颅内出血、脑结构畸形的发生增加癫痫发生风险,在临床上应给予相应重视。Objective: To explore the risk factors of cerebral palsy complicated with epilepsy in children. Methods: The clinical data of 80 children with cerebral palsy treated in Shenzhen Children’s Hospital of Guangdong Province from July 2018 to July2020 were retrospectively analyzed. According to whether they were complicated with epilepsy, they were divided into two groups:epilepsy group with epilepsy(n=28) and non-epilepsy group without epilepsy(n=52). The data of the two groups were compared,and univariate analysis and Logistic regression analysis were performed. Results: In 80 cases of children with cerebral palsy, 28 cases were complicated with epilepsy, with the incidence rate of 35.00%. The incidence of low birth weight, encephalomalacia,intracranial hemorrhage, and brain structural malformation in the epilepsy group was significantly higher than that in the nonepilepsy group, with statistically significant difference(P<0.05). Logistic multivariate analysis showed that low birth weight(OR=2.785), encephalomalacia(OR=3.181), intracranial hemorrhage(OR= 3.474), and brain structural malformation(OR=5.615) were independent risk factors of cerebral palsy complicated with epilepsy(P<0.05). Conclusion: The incidence of low birth weight,encephalomalacia, intracranial hemorrhage, and brain structural malformation in children with cerebral palsy increases the risk of epilepsy, which should be paid more attention in clinic.

关 键 词：小儿脑性瘫痪 癫痫 颅内出血 脑结构畸形 干预对策 

分 类 号：R742.3[医药卫生—神经病学与精神病学] R742.1[医药卫生—临床医学]