采用惰性气体增强空心针-环离子源放电的高场非对称波形离子迁移谱系统研究  

Study on High-field Asymmetric Waveform Ion Mobility Spectrometry System Using Inert Gas to Enhance Discharge of Hollow Needle-Ring Ion Source

作　　者：曾鸿达 杜晓霞 潘家锴 王一飞 陈真诚[1] 李华[1] ZENG Hong-Da;DU Xiao-Xia;PAN Jia-Kai;WANG Yi-Fei;CHEN Zhen-Cheng;LI Hua(Key Laboratory of Biomedical Sensors and Intelligent Instruments in Guangxi Universities,School of Life and Environmental Sciences,Guilin University of Electronic Technology,Guilin 541004,China)

机构地区：[1]桂林电子科技大学生命与环境科学学院,广西高校生物医学传感与智能仪器重点实验室,桂林541004

出　　处：《分析化学》2022年第5期680-691,I0001,I0002,共14页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.62163009,61864001);广西自然科学基金重点项目(No.2021JJD170019);广西自动检测技术与仪器重点实验室主任基金项目(No.YQ21111)资助。

摘　　要：分辨力和灵敏度是表征高场非对称波形离子迁移谱(FAIMS)性能的两个重要参数。为同时提高平板型FAIMS的分辨力和灵敏度,本研究提出了一种惰性气体增强放电的空心针-环离子源。在标准大气压下,向针-环离子源通入惰性气体氦气和氩气,以提高离子源的电离效率,实现挥发性有机物的有效电离。在氮气流速1.8 L/min、射频电压(Radio frequency,RF)300 V的条件下,分别加入气体流速为0.2、0.3和0.4 L/min的氦气和氩气。与纯氮气相比,通入氦气后,丙酮、乙醇和乙酸乙酯的信号强度分别提高了19.07、17.26和10.85倍,通入氩气后的信号强度分别提高了4.86、13.37和4.63倍,且氦气、氩气和氮气的混合使FAIMS谱图出现了多个离子峰。实验结果表明,通入氦气和氩气均能同时提高分辨力和灵敏度,并且氦气的效果优于氩气。质谱实验结果和潘宁电离理论分析结果表明,电离产生的主要离子为单聚体离子和二聚体离子。本研究为提高FAIMS系统的分辨力和灵敏度提供了新方法。Resolving power and sensitivity are two important parameters to characterize the performance of high field asymmetric waveform ion mobility spectrometry(FAIMS).To simultaneously improve the resolving power and sensitivity of flat plate FAIMS,a hollow needle-ring ion source for inert gas enhanced discharge is proposed in this work.At standard atmospheric pressure,inert gases helium and argon are introduced into the needle-ring ion source to improve the ionization efficiency of the ion source and achieve effective ionization of VOCs.Helium and argon gas with gas flow rates of 0.2,0.3 and 0.4 L/min were added at a nitrogen flow rate of 1.8 L/min and a radio frequency voltage(RF)of 300 V,respectively.Compared with pure nitrogen,the signal intensities of acetone,ethanol and ethyl acetate were increased by 19.07,17.26 and 10.85 times,respectively,after passing helium,and 4.86,13.37 and 4.63 times,respectively,after passing argon,and the mixture of helium,argon and nitrogen resulted in multiple ion peaks in the FAIMS spectrum.The results showed that both helium and argon could improve both resolving power and sensitivity,and that helium was more effective than argon.Mass spectrometry experiments and penning ionization theory analysis showed that the main ions produced by ionization were monomeric and dimeric ions.This study provided new ideas and methods to improve the resolving power and sensitivity of FAIMS systems.

关 键 词：高场非对称波形离子迁移谱 惰性气体 质谱 分辨力 灵敏度 

分 类 号：TH83[机械工程—仪器科学与技术]